Capsular polysaccharide-protein conjugate vaccines

被引：12
|
作者：
Sood, RK
Fattom, A
Pavliak, V
Naso, RB
机构：
[1] W.W. Karakawa Microbial Pathogenesis, NABI, Rockville, MD 20852
来源：
DRUG DISCOVERY TODAY | 1996年 / 1卷 / 09期
关键词：
D O I：
10.1016/1359-6446(96)10032-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The conjugation of polysaccharides to carrier proteins generally enhances polysaccharide immunogenicity and renders the immune response T-cell dependent, Such enhancement of immunogenicity has made the use of conjugate vaccines possible in populations that are otherwise unresponsive to polysaccharide vaccines. Here, the authors discuss the value of capsular polysaccharide vaccines, their ability to elicit protective immunity against infectious bacteria, the selection of appropriate polysaccharides and carrier proteins, and the applications of the resultant conjugate vaccines.
引用
收藏
页码：381 / 387
页数：7
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