Palladium-catalyzed fluorination of carbon-hydrogen bonds

被引：510
|
作者：
Hull, Kami L. [1 ]
Anani, Waseem Q. [1 ]
Sanford, Melanie S. [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 22期
关键词：
D O I：
10.1021/ja061943k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This communication describes the development of a new Pd-catalyzed method for the fluorination of carbon-hydrogen bonds. A key step of these transformations involves palladium-mediated carbon-fluorine couplinga much sought after, but previously unprecedented, transformation. These reactions were successfully achieved under oxidative conditions using electrophilic N-fluoropyridinium reagents. Microwave irradiation in the presence of catalytic palladium acetate served as optimal conditions for the fluorination of C-H bonds in a variety of substituted 2-arylpyridine and 8-methylquinoline derivatives. Copyright © 2006 American Chemical Society.
引用
收藏
页码：7134 / 7135
页数：2
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