Analysis of the Association of Haplotypes with Alzheimer's Disease and Mild Cognitive Impairment in the Russian Population

被引：0

作者：

Vagaitseva, K. V. ^{[1
]}

Bocharova, A., V ^{[1
]}

Kolesnikova, E. A. ^{[2
]}

Markova, V. V. ^{[1
]}

Makeeva, O. A. ^{[1
]}

Minaycheva, L., I ^{[1
]}

Zhukova, I. A. ^{[3
]}

Zhukova, N. G. ^{[3
]}

Stepanov, V. A. ^{[1
]}

机构：

[1] Tomsk Natl Med Res Ctr, Res Inst Med Genet, Tomsk 634050, Russia

[2] Tomsk State Univ, Tomsk 634050, Russia

[3] Siberian State Med Univ, Tomsk 634050, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2020年 / 56卷 / 10期

关键词：

analysis of associations; linkage disequilibrium; Alzheimer's disease; haplotypes; Russian population; LINKAGE DISEQUILIBRIUM; VARIANTS; CR-1;

D O I：

10.1134/S1022795420100130

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Haplotype associations of 894 DNA samples of elderly people from the Russian population of Tomsk were analyzed using 49 SNPs (single nucleotide polymorphisms). As the analyzed markers, SNPs were selected that showed an association with Alzheimer's disease or variability of cognitive abilities in genome-wide association studies. As a result of the analysis, blocks on chromosomes 1, 2, 6, 8, 11, 19, and 20 were identified. Significant associations were shown, taking into account 50 000 permutations, for haplotypes localized on chromosomes 1 and 19 in the genesCR1andAPOE,APOC1, respectively. Our results confirm the role of theAPOEandCR1genes in the pathogenesis of Alzheimer's disease in the Russian population.

引用

页码：1272 / 1276

页数：5

共 50 条

[41] Analysis of the Relationship of Cognitive Impairment and Functional Impairment in Mild Alzheimer’s Disease in EXPEDITION 3
Hong Liu-Seifert
E. Siemers
K. Sundell
M. Mynderse
J. Cummings
R. Mohs
P. Aisen
The Journal of Prevention of Alzheimer's Disease, 2018, 5 : 184 - 187
[42] Analysis of the Relationship of Cognitive Impairment and Functional Impairment in Mild Alzheimer's Disease in EXPEDITION 3
Liu-Seifert, H.
Siemers, E.
Sundell, K.
Mynderse, M.
Cummings, J.
Mohs, R.
Aisen, P.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE, 2018, 5 (03): : 184 - 187
[43] Cognitive estimation impairment in Alzheimer disease and mild cognitive impairment
Levinoff, EJ
Phillips, NA
Verret, L
Babins, L
Kelner, N
Akerib, V
Chertkow, H
NEUROPSYCHOLOGY, 2006, 20 (01) : 123 - 132
[44] An Epidemiological-based Regression Analysis of Alzheimer's disease and Mild Cognitive Impairment Converts in the Female Population
Khan, Afreen
Zubair, Swaleha
Khan, Samreen
IEEE EUROCON 2021 - 19TH INTERNATIONAL CONFERENCE ON SMART TECHNOLOGIES, 2021, : 77 - 81
[45] Association of Mediterranean Diet with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis
Singh, Balwinder
Parsaik, Ajay K.
Mielke, Michelle M.
Erwin, Patricia J.
Knopman, David S.
Petersen, Ronald C.
Roberts, Rosebud O.
JOURNAL OF ALZHEIMERS DISEASE, 2014, 39 (02) : 271 - 282
[46] Biracial Population Study of Mortality in Mild Cognitive Impairment and Alzheimer Disease
Wilson, Robert S.
Aggarwal, Neelum T.
Barnes, Lisa L.
Bienias, Julia L.
de Leon, Carlos F. Mendes
Evans, Denis A.
ARCHIVES OF NEUROLOGY, 2009, 66 (06) : 767 - 772
[47] Mild cognitive impairment in the general population:: Occurrence and progression to Alzheimer disease
Palmer, Katie
Backman, Lars
Winblad, Bengt
Fratiglioni, Laura
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2008, 16 (07): : 603 - 611
[48] Olfactory memory in mild cognitive impairment and Alzheimer's disease
Audronyte, Egle
Sutnikiene, Vaiva
Pakulaite-Kazliene, Gyte
Kaubrys, Gintaras
FRONTIERS IN NEUROLOGY, 2023, 14
[49] Mild cognitive impairment -: an early stage of Alzheimer's disease?
Almkvist, O
Basun, H
Bäckman, L
Herlitz, A
Lannfelt, L
Small, B
Viitanen, M
Wahlund, LO
Winblad, B
JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT, 1998, (54): : 21 - 29
[50] Olfaction in patients with mild cognitive impairment and Alzheimer's disease
Djordjevic, Jelena
Jones-Gotman, Marilyn
De Sousa, Kathy
Chertkow, Howard
NEUROBIOLOGY OF AGING, 2008, 29 (05) : 693 - 706

← 1 2 3 4 5 →