Analysis of the Association of Haplotypes with Alzheimer's Disease and Mild Cognitive Impairment in the Russian Population

被引：0
|
作者：
Vagaitseva, K. V. [1 ]
Bocharova, A., V [1 ]
Kolesnikova, E. A. [2 ]
Markova, V. V. [1 ]
Makeeva, O. A. [1 ]
Minaycheva, L., I [1 ]
Zhukova, I. A. [3 ]
Zhukova, N. G. [3 ]
Stepanov, V. A. [1 ]
机构：
[1] Tomsk Natl Med Res Ctr, Res Inst Med Genet, Tomsk 634050, Russia
[2] Tomsk State Univ, Tomsk 634050, Russia
[3] Siberian State Med Univ, Tomsk 634050, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2020年 / 56卷 / 10期
关键词：
analysis of associations; linkage disequilibrium; Alzheimer's disease; haplotypes; Russian population; LINKAGE DISEQUILIBRIUM; VARIANTS; CR-1;
D O I：
10.1134/S1022795420100130
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Haplotype associations of 894 DNA samples of elderly people from the Russian population of Tomsk were analyzed using 49 SNPs (single nucleotide polymorphisms). As the analyzed markers, SNPs were selected that showed an association with Alzheimer's disease or variability of cognitive abilities in genome-wide association studies. As a result of the analysis, blocks on chromosomes 1, 2, 6, 8, 11, 19, and 20 were identified. Significant associations were shown, taking into account 50 000 permutations, for haplotypes localized on chromosomes 1 and 19 in the genesCR1andAPOE,APOC1, respectively. Our results confirm the role of theAPOEandCR1genes in the pathogenesis of Alzheimer's disease in the Russian population.
引用
收藏
页码：1272 / 1276
页数：5
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