Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

被引：13
|
作者：
Wang, Xiaoling [1 ]
Tabudravu, Jioji [1 ]
Rateb, Mostafa Ezzat [1 ,3 ]
Annand, Krystal Joan [1 ]
Qin, Zhiwei [1 ]
Jaspars, Marcel [1 ]
Deng, Zixin [2 ]
Yu, Yi [2 ]
Deng, Hai [1 ]
机构：
[1] Univ Aberdeen, Marine Biodiscovery Ctr, Dept Chem, Aberdeen AB24 3LZ, Scotland
[2] Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatory Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China
[3] Beni Suef Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf 62111, Egypt
来源：
MOLECULAR BIOSYSTEMS | 2013年 / 9卷 / 06期
基金：
中国国家自然科学基金;
关键词：
HALOGENATION; BIOSYNTHESIS; SYRB2;
D O I：
10.1039/c3mb70081j
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G(2-3), respectively.
引用
收藏
页码：1286 / 1289
页数：4
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