pH-Responsive Self-Assembly by Molecular Recognition on a Macroscopic Scale

被引：58
|
作者：
Zheng, Yongtai [1 ]
Hashidzume, Akihito [1 ]
Harada, Akira [1 ,2 ]
机构：
[1] Osaka Univ, Dept Macromol Sci, Grad Sch Sci, Toyonaka, Osaka 5600043, Japan
[2] Japan Sci & Technol Agcy JST, CREST, Chiyoda Ku, Tokyo 1020076, Japan
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2013年 / 34卷 / 13期
关键词：
cyclodextrin; dansyl; molecular recognition; pH-responsive; self-assembly; DRUG-DELIVERY; BETA-CYCLODEXTRIN; FLUORESCENCE; SELECTIVITY; INCLUSION; SYSTEM;
D O I：
10.1002/marc.201300324
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Macroscopic pH-responsive self-assembly is successfully constructed by polyacrylamide(pAAm)-based gels carrying dansyl (Dns) and -cyclodextrin (CD) residues, which are represented as Dns-gel and CD-gel, respectively. Dns-gel and CD-gel assemble together at pH 4.0, but disassemble at pH 3.0. The adhesion strengths for pairs of Dns-gel/CD-gel increase with increasing pH. The fluorescence study on the model system of pAAm modified with 1 mol% Dns moieties (pAAm/Dns) reveals that Dns residues are protonated at a lower pH, which results in the reduction in binding constant (K) for Dns residues and CD.
引用
收藏
页码：1062 / 1066
页数：5
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