HIGH-THROUGHPUT WHITE BLOOD CELLS (LEUKOCYTES) SEPARATION AND ENRICHMENT FROM WHOLE BLOOD BY HYDRODYNAMIC AND INERTIAL FORCE

被引：0

作者：

Tseng, Horas-Cendana ^{[1
]}

Wu, Ren-Guei ^{[2
]}

Chang, Hwan-You ^{[3
]}

Tseng, Fan-Gang ^{[1
,2
,4
]}

机构：

[1] Natl Tsing Hua Univ, Inst Nano Engn & Micro Syst, Hsinchu, Taiwan

[2] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu, Taiwan

[3] Natl Tsing Hua Univ, Dept Life Sci, Hsinchu, Taiwan

[4] Div Mech, Res Ctr Appl Sci, Hsinchu, Taiwan

来源：

2012 IEEE 25TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS) | 2012年

关键词：

FILTRATION;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

To solve clogging in microchannel and low separation rate in microfluidic devices that containing high concentration whole blood cells (4.3x10(6) cells/mu l) with the remaining <1% consisting peripheral blood leukocytes and platelets [1-2]. In this work we introduce a like-biomimetic structure to separate red blood cells from whole blood and to enrich leukocytes (white blood cells) through the elastic properties of blood cell by the interaction of inertial force, shear lift, and wall crowding effect in a continuous flow system. A high separation efficiency (similar to 84%) and high throughput flow rate (200 mu l/s or 10ml/min) was obtained in this microfluidic chip.

引用

页数：4

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