New streptophenazines from marine Streptomyces sp 182SMLY

被引：16
|
作者：
Liang, Ying [1 ]
Chen, Lu [1 ]
Ye, Xuewei [1 ]
Anjum, Komal [1 ]
Lian, Xiao-Yuan [2 ]
Zhang, Zhizhen [1 ]
机构：
[1] Zhejiang Univ, Ocean Coll, Zhoushan Campus, Zhoushan, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 04期
基金：
美国国家科学基金会;
关键词：
Streptomyces sp 182SMLY; (-)-streptophenazines M-O; (-)-streptophenazine B; antibacterial activity; ABSOLUTE-CONFIGURATION; SUBSTITUTED PHENAZINES; SPECTRA; ANALOGS; STRAIN;
D O I：
10.1080/14786419.2016.1169419
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Six phenazines including three new ones were isolated from the culture of a marine actinomycete Streptomyces sp. 182SMLY. Based on the analyses of NMR, HRESIMS, optical rotation value, and CD data, the structures of these isolated compounds were determined as new phenazines of (-)-streptophenazines M-O and known phenazines of 1-carbomethoxyphenazine and (-)-streptophenazines A and B. (-)-Streptophenazine B showed activity in suppressing the growth of methicillin-resistant Staphylococcus aureus with MIC value of 4.2 mu g/mL. [GRAPHICS] .
引用
收藏
页码：411 / 417
页数：7
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