Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

被引：4
|
作者：
Filippi, Beatrice Maria [1 ]
Alessi, Dario R. [1 ]
机构：
[1] Univ Dundee, MRC, Prot Phosphorylat Unit, Coll Life Sci, Dundee DD1 5EH, Scotland
来源：
JOURNAL OF CELL BIOLOGY | 2008年 / 183卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1083/jcb.200809056
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A question preoccupying many researchers is how signal transduction pathways control metabolic processes and energy production. A study by Jang et al. ( Jang, C., G. Lee, and J. Chung. 2008. J. Cell Biol. 183: 11 - 17) provides evidence that in Drosophila melanogaster a signaling network controlled by the LKB1 tumor suppressor regulates trafficking of an Sln/dMCT1 monocarboxylate transporter to the plasma membrane. This enables cells to import additional energy sources such as lactate and butyrate, enhancing the repertoire of fuels they can use to power vital activities.
引用
收藏
页码：7 / 9
页数：3
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