The Tissue Distribution and Pharmacokinetics of Long-Circulating β-Elemene Liposomes in Mice

The aim of this research was to prepare beta-elemene long-circulating liposomes and understand the distribution, elimination, and localization profile of beta-elemene in mice tissues. Beta-elemene long-circulating liposome was prepared by ethanol injection method. Gas chromatography (GC) was established to determine the concentration of beta-elemene in rat plasma and tissues (heart, liver, spleen, lungs, kidneys, intestine and brain) after intravenous injection of beta-elemene long-circulating liposome and conventional liposomes, respectively. The alpha, T-1/2 beta, K12, and AUC of beta-elemene long-circulating liposome groups were higher compared with conventional liposomes, and the T-1/ 2 alpha, Vc, CL, and K10 of the latter were lower; beta-elemene long-circulating liposomes were distributed manly in liver, spleen and lungs, which could reduce the accumulation in the heart. The results indicate that beta-elemene long-circulating liposome is a controlled long-efficient formulation and the cardiotoxicity was reduced.