p70S6 kinase phosphorylation for pharmacodynamic monitoring

被引：13

作者：

Hartmann, B. ^{[1
]}

机构：

[1] Innere Med Klin 1, Zentrum Innere Med, Sekt Nephrol, D-89070 Ulm, Germany

来源：

CLINICA CHIMICA ACTA | 2012年 / 413卷 / 17-18期

关键词：

mTOR inhibitor; Rapamycin; Sirolimus; Everolimus; Pharmacodynamic monitoring; Kidney transplantation; RENAL-TRANSPLANTATION; P70(S6K) PHOSPHORYLATION; RAPAMYCIN; MTOR; SIROLIMUS; INHIBITOR; GROWTH; TARGET; KIDNEY; CANCER;

D O I：

10.1016/j.cca.2012.03.023

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Inhibitors of the mammalian target of rapamycin (mTOR) are administered as immunosuppressant as well as antineoplastic agents. Because of the narrow therapeutic index of mTOR inhibitors, drug monitoring is required, and this is usually done by measuring blood drug levels. Increasing knowledge of the signaling pathways of the mTOR protein kinase provides an opportunity for pharmacodynamic drug monitoring. With the different laboratory methods it is becoming possible to measure new biomarkers to control the influence of mTOR activity. One of these biomarkers is phospho-S6 kinase, with its isoform p70S6K. (C) 2012 Published by Elsevier B.V.

引用

页码：1387 / 1390

页数：4

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