Tuning the size of gelatin nanoparticles produced by nanoprecipitation

被引：5
|
作者：
Khan, Saeed Ahmad [1 ]
Ali, Hussain [2 ]
Ihsan, Ayesha [3 ]
Sabir, Nadeem [4 ]
机构：
[1] Kohat Univ Sci & Technol, Dept Pharm, Kohat 26000, Pakistan
[2] Quaid I Azam Univ, Dept Pharm, Islamabad, Pakistan
[3] NIBGE, Div Ind Biotechnol, Faisalabad, Pakistan
[4] Govt Coll Univ, Dept Phys, Faisalabad, Pakistan
来源：
COLLOID JOURNAL | 2015年 / 77卷 / 05期
关键词：
POLYMERIC NANOPARTICLES; 2-STEP DESOLVATION; DELIVERY-SYSTEM; CELL UPTAKE; DRUG; OPTIMIZATION;
D O I：
10.1134/S1061933X15050105
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The aim of the study was to control the size of gelatin nanoparticles under varied conditions of nanoprecipitation. The gelatin concentration in the solvent phase and different combination of nonsolvents was used to see influence on the size, polydispersity and recovery yield of produced nanoparticles. The size of the nanoparticles was determined by dynamic light scattering. The yield of gelatin nanoparticles after freezedrying was found gravimetrically. The morphology of nanoparticles was studied by scanning electron microscopy. The results suggest that the size of nanoparticles can be tuned within a range 250-350 nm with low polydispersity index because of the inhibition of particle aggregation during crosslinking. The produced nanoparticles are of spherical shape with a smooth surface. We found that the recovery yield was also dependent on the gelatin concentration in the solvent phase.
引用
收藏
页码：672 / 676
页数：5
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