Recent advances in the development of histone deacylase SIRT2 inhibitors

被引：20
|
作者：
Yang, Wenyu [1 ]
Chen, Wei [1 ]
Su, Huilin [1 ]
Li, Rong [1 ]
Song, Chen [1 ]
Wang, Zhouyu [2 ]
Yang, Lingling [1 ]
机构：
[1] Xihua Univ, Coll Food & Bioengn, Chengdu 610039, Peoples R China
[2] Xihua Univ, Coll Sci, Chengdu 610039, Sichuan, Peoples R China
来源：
RSC ADVANCES | 2020年 / 10卷 / 61期
关键词：
ANTIPROLIFERATIVE PROPERTIES; SELECTIVE INHIBITORS; STRUCTURAL BASIS; BINDING-SITE; IN-VITRO; DEACETYLASE; DISCOVERY; POTENT; IDENTIFICATION; SIRTUINS;
D O I：
10.1039/d0ra06316a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sirtuin 2 (SIRT2) is an important and special member of the atypical histone deacetylase Sirtuin (SIRT) family. Due to its extensive catalytic effects, SIRT2 can regulate autophagy, myelination, immunity, inflammation and other physiological processes. Recent evidence revealed that dysregulation of human SIRT2 activity is associated with the pathogenesis and prognosis of cancers, Parkinson's disease and other disorders; thus SIRT2 is a promising target for potential therapeutic intervention. This review presents a systematic summary of nine chemotypes of small-molecule SIRT2 inhibitors, particularly including the discovery and structural optimization strategies, which will be useful for future efforts to develop new inhibitors targeting SIRT2 and associated target proteins.
引用
收藏
页码：37382 / 37390
页数：9
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