A Sense of Self: RIG-I's Tolerance to Host RNA

被引：1
|
作者：
Schoggins, John W. [1 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA
来源：
IMMUNITY | 2015年 / 43卷 / 01期
关键词：
STRANDED-RNA; RECOGNITION; ACTIVATION; MDA5;
D O I：
10.1016/j.immuni.2015.06.022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner et al. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.
引用
收藏
页码：1 / 2
页数：2
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