Synthesis and Evaluation of Some Coumarin Based Schiff's Bases as Potential Antimicrobial Agents'

被引：1
|
作者：
Bansode, Vishakha [1 ]
Deodhar, Meenakshi N. [1 ]
机构：
[1] PDEAs Seth Govind Raghunath Sable Coll Pharm, Dept Pharmaceut Chem, Pune 412301, Maharashtra, India
来源：
E-JOURNAL OF CHEMISTRY | 2012年 / 9卷 / 04期
关键词：
Coumarin; Pyrazoline; Schiff's base; Antimicrobial activity; DERIVATIVES;
D O I：
10.1155/2012/791091
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of the title compounds 3-(4-(4, 5-dihydro-5-(substituted phenyl)-1H-3-pyrazolyl) phenylimino) methyl)-4-chloro-2H-chromen-2-one 5(a-g) have been synthesized. These compounds were characterized on the basis of their spectral (IR, H-1 NMR) data and evaluated for antimicrobial activity in vitro against gram positive bacteria, gram negative bacteria and fungi. The compound (5b) was found to be the most active with MIC of 20 mu g/ml against all the tested organisms.
引用
收藏
页码：2079 / 2088
页数：10
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