The effect of rat serum albumin on the healing of excisional wounds in rats

Albumin is often added as a stabilizer to various biological agents and contains contaminants which might confound wound healing research with highly purified growth factors stabilized with albumin. This invivo study was designed to determine the effect of commercial rat serum albumin (RSA) on the healing of excisional wounds in rats. Dorsal excisions through the panniculus carnosus were treated once daily for ten doses with either RSA, heat-inactivated RSA, or its buffered vehicle. Times to wound closure and strength of the healed wounds were compared among the three treatments. There were no significant differences (ANOVA, p > 0.10) in the rates of wound closure or in the wound breaking strengths among the treatment groups.