Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Myxomatous Mitral Valve Disease Receiving Pimobendan or Benazepril The QUEST Study

被引：1

作者：

Haggstrom, Jens ^{[1
]}

Boswood, Adrian ^{[2
]}

O'Grady, Michael ^{[3
]}

Jons, Olaf ^{[4
]}

Smith, Sarah ^{[5
,6
]}

Borgarelli, Michele ^{[7
]}

Gavaghan, Brad ^{[8
]}

Kresken, Jan-Gerd ^{[9
]}

Patteson, Mark ^{[10
]}

Ablad, Bjorn ^{[11
]}

Bussadori, Claudio M. ^{[12
]}

Glaus, Tony ^{[13
]}

Kovacevic, Alan ^{[14
]}

Rapp, Martin ^{[15
]}

Santilli, Roberto A. ^{[16
]}

Tidholm, Anna ^{[17
]}

Eriksson, Anders ^{[18
]}

Belanger, Marie Claude ^{[19
]}

Deinert, Michael ^{[20
]}

Little, Chris J. L. ^{[21
]}

Kvart, Clarence ^{[1
]}

French, Anne ^{[22
]}

Ronn-Landbo, Mette ^{[23
]}

Wess, Gerhard ^{[24
]}

Eggertsdottir, Anna ^{[25
]}

O'Sullivan, M. Lynne ^{[3
]}

Schneider, Matthias ^{[26
]}

Lombard, Christophe W. ^{[27
]}

Dukes-McEwan, Joe ^{[28
]}

Willis, Ruth ^{[28
]}

Louvet, Alexandre ^{[29
]}

DiFruscia, Rocky ^{[19
]}

机构：

[1] Swedish Univ Agr Sci, Fac Vet Med & Anim Sci, S-75007 Uppsala, Sweden

[2] Royal Vet Coll London, London, England

[3] Ontario Vet Coll, Guelph, ON, Canada

[4] Boehringer Ingelheim Vetmed GmbH, Ingelheim, Germany

[5] Scarsdale Vet Hosp, Derby, England

[6] Northwest Surg, Sutton Weaver, Cheshire, England

[7] Fac Med Vet, Turin, Italy

[8] Vet Cardiol & Imaging Pty Ltd, Dayboro, Qld, Australia

[9] Tierarztl Klin Kaiserberg, Duisburg, Germany

[10] Vale Referrals, Stinchcombe, Dursley, England

[11] Bla Stjarnan Anim Hosp, Gothenburg, Sweden

[12] Clin Gran Sasso, Milan, Italy

[13] Univ Zurich, Fak Vet Med, CH-8006 Zurich, Switzerland

[14] Free Univ Berlin, Berlin, Germany

[15] Reg Djursjukhuset Stromsholm, Kolback, Sweden

[16] Clin Vet Malpensa, Samarate Varese, Italy

[17] Albano Anim Hosp, Stockholm, Sweden

[18] Univ Helsinki, Dept Equine & Small Anim Med, Helsinki, Finland

[19] Univ Montreal, Fac Med Vet, St Hyacinthe, PQ J2S 7C6, Canada

[20] Tierklin Sandpfad, Wiesloch, Germany

[21] Barton Vet Hosp, Canterbury, Kent, England

[22] Royal Dick Sch Vet Studies, Roslin, Midlothian, Scotland

[23] Aalborg Dyrehosp, Aalborg, Denmark

[24] Univ Munich, Med Kleintierklin, D-81377 Munich, Germany

[25] Norges Vet Hogskole, Oslo, Norway

[26] Univ Giessen, Fak Vet Med, D-35390 Giessen, Germany

[27] Univ Bern, Dept Klin Vet Med, Bern, Switzerland

[28] Univ Glasgow, Glasgow, Lanark, Scotland

[29] Clin Vet, St Germain En Laye, France

来源：

KLEINTIERPRAXIS | 2014年 / 59卷 / 03期

关键词：

canine; mitral regurgitation; mortality; therapy; CONGESTIVE-HEART-FAILURE; DOBERMAN-PINSCHERS; BODY-TEMPERATURE; EFFICACY; SURVIVAL; MORTALITY; PREVENTION; ENALAPRIL; SYMPTOMS; OUTCOMES;

D O I：

10.2377/0023-2076-59-117

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Background: Myxomatous mitral valve disease (MMVD) is an important cause of morbidity and mortality in dogs Objectives: To compare, throughout the period of follow-up of dogs that had not yet reached the primary endpoint, the longitudinal effects of pimobendan versus benazepril hydrochloride treatment on quality-of-life (QoL) variables, concomitant congestive heart failure (CHF) treatment, and other outcome variables in dogs suffering from CHF secondary to MMVD. Animals: A total of 260 dogs in CHF because of MMVD. Methods A prospective single-blinded study with dogs randomized to receive pimobendan (0.4-0.6 mg/kg/day) or benazepril hydrochloride (0.25-1.0 mg/kg/day) Differences in outcome variables and time to intensification of CHF treatment were compared. Results: A total of 124 dogs were randomized to pimobendan and 128 to benazepril. No difference was found between groups in QoL variables during the trial. Time from inclusion to 1st intensification of CHF treatment was longer in the pimobendan group (pimobendan 98 days, IQR 30-276 days versus benazepril 59 days, IQR 11-121 days; P = .0005). Postinclusion, dogs in the pimobendan group had smaller heart size based on VHS score (P = .013) and left ventricular diastolic (P = .035) and systolic (P = 0044) dimensions, higher body temperature (P = .030), serum sodium (P = .0027), and total protein (P = .0003) concentrations, and packed cell volume (P = .030) Incidence of arrhythmias was similar in treatment groups. Conclusions and clinical importance: Pimobendan versus benazepril resulted in similar QoL during the study, but conferred increased time before intensification of CHF treatment Pimobendan treatment resulted in smaller heart size, higher body temperature, and less retention of free water.

引用

页码：117 / +

页数：16

共 32 条

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Athanasiou, Labrini V. V.
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Rubio, Camila P. P.
Ceron, Jose J.
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Polizopoulou, Zoe S. S.
VETERINARY SCIENCES, 2023, 10 (01)
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Czech, A. A.
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JOURNAL OF VETERINARY CARDIOLOGY, 2024, 51 : 105 - 115

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