Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region

被引：201
|
作者：
Riehle, MM
Markianos, K
Niaré, O
Xu, JN
Li, J
Touré, AM
Podiougou, B
Oduol, F
Diawara, S
Diallo, M
Coulibaly, B
Ouatara, A
Kruglyak, L
Traoré, SF
Vernick, KD [1 ]
机构：
[1] Univ Minnesota, Ctr Microbial & Plant Genom, St Paul, MN 55108 USA
[2] Univ Minnesota, Dept Microbiol, St Paul, MN 55108 USA
[3] Fred Hutchinson Canc Res Ctr, Program Computat Biol, Seattle, WA 98109 USA
[4] Univ Bamako, Dept Epidemiol Affectat Parasitaires, Bamako, Mali
[5] Princeton Univ, Carl Icahn Lab, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA
[6] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
来源：
SCIENCE | 2006年 / 312卷 / 5773期
关键词：
D O I：
10.1126/science.1124153
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.
引用
收藏
页码：577 / 579
页数：3
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