Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RaIGDS

被引：9

作者：

Isomura, M ^{[1
]}

Okui, K ^{[1
]}

Fujiwara, T ^{[1
]}

Shin, S ^{[1
]}

Nakamura, Y ^{[1
]}

机构：

[1] OTSUKA PHARMACEUT CO LTD,OTSUKA GEN RES INST,TOKUSHIMA 77101,JAPAN

来源：

CYTOGENETICS AND CELL GENETICS | 1996年 / 74卷 / 04期

关键词：

D O I：

10.1159/000134431

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have isolated a novel human cDNA, designated RAB2L, that encodes a protein homologous to Pal guanine nucleotide dissociation stimulator (RalGDS). The predicted sequence of 122 amino acids revealed 39.5% identity with the C-terminal region of human RalGDS. As the C-terminal region of RalCDS is considered to interact with RAS, the product of this novel gene may also play some role in the ras-mediated signal transduction pathway. Northern analysis revealed that the gene RAB2L is expressed in all human tissues examined. We assigned this gene locus to chromosome band 6p21.3 by fluorescence in situ hybridization.

引用

页码：263 / 265

页数：3

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