JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp. OPMA00071

被引：13
|
作者：
Kawahara, Teppei [1 ]
Fujiwara, Takeshi [2 ]
Kagaya, Noritaka [1 ]
Shin-ya, Kazuo [3 ,4 ]
机构：
[1] JBIC, Koto Ku, 2-4-7 Aomi, Tokyo 1350064, Japan
[2] OP Bio Factory Co Ltd, Okinawa Life Sci Res Ctr, 107 5-8 Suzaiki, Okinawa, Okinawa 9042234, Japan
[3] Natl Inst Adv Ind Sci & Technol, Koto Ku, 2-4-7 Aomi, Tokyo 1350064, Japan
[4] Univ Tokyo, Biotechnol Res Ctr, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan
来源：
JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 03期
关键词：
D O I：
10.1038/s41429-017-0010-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
During the course of constructing a natural product library for drug screening consisting of microbial culture extracts originated from marine samples, we evaluated natural product components profiles via UPLC TOF-MS and routine biological tests for cytotoxic and antibiotic activities for all of the culture extract samples. By combination of chemical screening and biological activities, we succeeded in discovering a 20-membered macrolactam antibiotic subsequently designated JBIR-150 (1) from a marine-derived actinomycete identified as Streptomyces sp. that was isolated from an Okinawan marine sediment. The chemical structure of 1 was determined by interpreting NMR spectroscopic and mass spectrometric data. Compound 1 exhibited moderate cytotoxicity against MESO-1 and Jurkat cells.
引用
收藏
页码：390 / 392
页数：3
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