Artificial intelligence in drug development: present status and future prospects

被引:353
|
作者
Mak, Kit-Kay [1 ,2 ]
Pichika, Mallikarjuna Rao [2 ,3 ]
机构
[1] Int Med Univ, Sch Postgrad Studies & Res, Kuala Lumpur, Malaysia
[2] Int Med Univ, Sch Pharm, Dept Pharmaceut Chem, Kuala Lumpur, Malaysia
[3] Int Med Univ, IRDI, Ctr Bioact Mol & Drug Delivery, Kuala Lumpur, Malaysia
关键词
PHARMACOLOGICAL-PROPERTIES; DEEP; GENERATION; DISCOVERY; DESIGN; TARGET; IDENTIFICATION; PRINCIPLES; REDUCE; HIT;
D O I
10.1016/j.drudis.2018.11.014
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Artificial intelligence (AI) uses personified knowledge and learns from the solutions it produces to address not only specific but also complex problems. Remarkable improvements in computational power coupled with advancements in AI technology could be utilised to revolutionise the drug development process. At present, the pharmaceutical industry is facing challenges in sustaining their drug development programmes because of increased R&D costs and reduced efficiency. In this review, we discuss the major causes of attrition rates in new drug approvals, the possible ways that AI can improve the efficiency of the drug development process and collaboration of pharmaceutical industry giants with AI-powered drug discovery firms.
引用
收藏
页码:773 / 780
页数:8
相关论文
共 50 条
  • [21] Artificial intelligence in psychiatry: Present and Future
    Ali, Syed Azhar
    RAWAL MEDICAL JOURNAL, 2023, 48 (04): : 803 - 804
  • [22] A Primer on the Present State and Future Prospects for Machine Learning and Artificial Intelligence Applications in Cardiology
    Manlhiot, Cedric
    van den Eynde, Jef
    Kutty, Shelby
    Ross, Heather J.
    CANADIAN JOURNAL OF CARDIOLOGY, 2022, 38 (02) : 169 - 184
  • [23] Artificial intelligence in capsule endoscopy development status and future expectations
    George, Ashwin A.
    Tan, Jin Lin
    Kovoor, Joshua G.
    Lee, Alvin
    Stretton, Brandon
    Gupta, Aashray K.
    Bacchi, Stephen
    George, Biju
    Singh, Rajvinder
    MINI-INVASIVE SURGERY, 2024, 8
  • [24] Artificial intelligence in the construction industry: A review of present status, opportunities and future challenges
    Abioye, Sofiat O.
    Oyedele, Lukumon O.
    Akanbi, Lukman
    Ajayi, Anuoluwapo
    Delgado, Juan Manuel Davila
    Bilal, Muhammad
    Akinade, Olugbenga O.
    Ahmed, Ashraf
    JOURNAL OF BUILDING ENGINEERING, 2021, 44
  • [25] SCHISTOSOMIASIS VACCINATION - HISTORICAL DEVELOPMENT, PRESENT STATUS AND FUTURE-PROSPECTS
    HSU, HF
    HSU, SYL
    EVELAND, LK
    CHINESE MEDICAL JOURNAL, 1980, 93 (05) : 297 - 312
  • [26] A Brief History of Artificial Intelligence: On the Past, Present, and Future of Artificial Intelligence
    Haenlein, Michael
    Kaplan, Andreas
    CALIFORNIA MANAGEMENT REVIEW, 2019, 61 (04) : 5 - 14
  • [27] Paediatric Drug Development in China: Current Status and Future Prospects
    Song, Lin
    Zhang, Ni
    Jiang, Ting-ting
    Jia, Yuntao
    Liu, Yao
    PEDIATRIC DRUGS, 2024, 26 (05) : 555 - 563
  • [28] Drug Information Provided to Patients and Public Present Regulatory Status and Future Prospects
    Sekino, Hidehito
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2021, 141 (03): : 381 - 385
  • [29] DRUG-ABUSE AND AIDS - PRESENT STATUS, PREVENTION, FUTURE-PROSPECTS
    LOWENSTEIN, W
    HAAS, C
    BOULY, N
    STERN, M
    FADLALLAH, JP
    DURAND, H
    ANNALES DE MEDECINE INTERNE, 1988, 139 (05): : 375 - 375
  • [30] Present status and prospects of artificial reefs in Thailand
    Kheawwongjan, Apitha
    Kim, Dong-Sun
    OCEAN & COASTAL MANAGEMENT, 2012, 57 : 21 - 33