Dehydroepiandrosterone increases β-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats

被引：25

作者：

Medina, MC

Souza, LC

Caperuto, LC

Anhêh, GF

Amanso, AM

Teixeira, VPA

Bordin, S

Carpinelli, AR

Britto, LRG

Barbieri, RL

Borella, MI

Carvalho, CRO ^{[1
]}

机构：

[1] Univ Sao Paulo, ICB, Dept Physiol & Biophys, BR-05389970 Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Biomed Sci, Dept Dev & Cell Biol, Sao Paulo, Brazil

[3] Coll Med Triangulo Mineiro, Dept Gen Pathol, Uberaba, MG, Brazil

来源：

FEBS LETTERS | 2006年 / 580卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

DHEA; insulin secretion; aged rats; Akt; IRS proteins; pancreatic islet;

D O I：

10.1016/j.febslet.2005.12.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of dehydroepiandrosterone (DHEA) on pancreatic islet function of aged rats, an animal model with impaired glucose-induced insulin secretion, was investigated. The following parameters were examined: morphological analysis of endocrine pancreata by immunohistochemistry; protein levels of insulin receptor, IRS-1, IRS-2, PI 3-kinase, Akt-1, and Akt-2; and static insulin secretion in isolated pancreatic islets. Pancreatic islets from DHEA-treated rats showed an increased beta-cell mass accompanied by increased Akt-1 protein level but reduced IR, IRS-1, and IRS-2 protein levels and enhanced glucose-stimulated insulin secretion. The present results suggest that DHEA may be a promising drug to prevent diabetes during aging. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：285 / 290

页数：6

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