The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

被引：26

作者：

Dale, CS

Gonçalves, LRC

Juliano, L

Juliano, MA

da Silva, AMM

Giorgi, R

机构：

[1] Butantan Inst, Lab Pathophysiol, BR-05503900 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Inst Pharmacol, Dept Biophys, BR-04044020 Sao Paulo, Brazil

[3] Butantan Inst, Immunopathol Lab, BR-05503900 Sao Paulo, Brazil

来源：

PEPTIDES | 2004年 / 25卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

hyperalgesia; edema; jararhagin; papain; MRP-14; S100A9;

D O I：

10.1016/j.peptides.2003.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：81 / 89

页数：9

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