Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P)

被引：2
|
作者：
Li, Yunpan [1 ,2 ,3 ]
Ibanez, David P. [1 ,2 ,3 ,4 ]
Fan, Wenxia [5 ]
Zhao, Ping [6 ]
Chen, Shuhan [1 ,2 ,3 ,4 ]
Abdul, Mazid Md [1 ,2 ,3 ]
Jiang, Yu [1 ,2 ,3 ]
Fu, Lixin [1 ,2 ,3 ,4 ]
Luo, Zhiwei [5 ]
Liu, Zhenhua [7 ,8 ]
Yang, Yueli [9 ]
Guo, Jifeng [7 ,8 ]
Volpe, Giacomo [1 ,2 ,3 ]
Kanwal, Shahzina [1 ,2 ,3 ]
Wang, Dongye [1 ,2 ,3 ]
Tang, Beisha [7 ,8 ]
Li, Wenjuan [1 ,2 ,3 ,5 ]
机构：
[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Integrat Biol, Guangzhou 510530, Peoples R China
[2] Key Lab Regenerat Biol, Guangzhou 510530, Peoples R China
[3] Guangdong Prov Key Lab Stem Cells & Regenerat Med, Guangzhou 510530, Peoples R China
[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[5] Guangzhou Med Univ, Guangzhou 511436, Peoples R China
[6] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510005, Peoples R China
[7] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China
[8] Cent South Univ, Natl Clin Res Ctr Geriatr Dis, Changsha 410008, Peoples R China
[9] Jilin Univ, Coll Vet Med, Changchun 130062, Peoples R China
来源：
STEM CELL RESEARCH | 2020年 / 46卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
DJ-1;
D O I：
10.1016/j.scr.2020.101845
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mutations occurring in the gene body of PARK7 (encoding DJ-1/PARK7) cause autosomal recessive early-onset parkinsonism (AREP). These mutations produce a loss of function and have been reported to lead to dopaminergic neuron degeneration in the substantia nigra. However, the underlying mechanisms are largely unknown. Here, we report the generation of a patient-derived induced pluripotent stem cell (iPSC) line carrying mutant DJ-1 (p.L10P). This cell line is a valuable tool for in vitro Parkinson's disease (PD) modeling and mechanistic studies.
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页数：5
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