A mitochondria-targeted zinc(II) phthalocyanine for photodynamic therapy

被引：27

作者：

Ge, Yanli ^{[1
,2
]}

Weng, Xiaocheng ^{[1
]}

Tian, Tian ^{[1
]}

Ding, Fei ^{[1
]}

Huang, Rong ^{[1
]}

Yuan, Libo ^{[1
]}

Wu, Jun ^{[1
]}

Wang, Tianlu ^{[1
]}

Guo, Pu ^{[1
]}

Zhou, Xiang ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Hubei, Peoples R China

[2] Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Hubei Novel Reactor & Green Chem Technol Key Lab, Wuhan 430073, Hubei, Peoples R China

来源：

RSC ADVANCES | 2013年 / 3卷 / 31期

基金：

美国国家科学基金会;

关键词：

CELL-DEATH; SILICON(IV) PHTHALOCYANINES; HELA-CELLS; APOPTOSIS; PHOTOSENSITIZERS;

D O I：

10.1039/c3ra41647j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A water-soluble zinc(II) phthalocyanine (ZnPc1) substituted with 1-(3-methyl) imidazoliumylethyloxy on the periphery was synthesized, and its subcellular localization and photodynamic activities were studied. ZnPc1 exhibited an almost exclusive mitochondrial-localizing property in human cervical carcinoma (HeLa) cells. Remarkable photocytotoxicity but low dark cytotoxic properties were observed for ZnPc1 in four different cancer cell lines. Photodynamic treatment (PDT) with ZnPc1 resulted in the generation of reactive oxygen species, a collapse of the mitochondrial membrane potential and chromatin condensation, all important hallmarks of apoptosis. The results are consistent with its mitochondrial localization property and qualify ZnPc1 as a promising PDT agent.

引用

页码：12839 / 12846

页数：8

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