Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome

被引：17

作者：

Tsai, Yi-Ju ^{[1
]}

Ramar, Kannan ^{[2
]}

Liang, Yao-Jen ^{[3
]}

Chiu, Po-Han ^{[4
]}

Powell, Nelson ^{[5
,6
]}

Chi, Chao-Yun ^{[4
]}

Lung, Tzu-Chen ^{[7
]}

Lin, Wesley Wen-Yang ^{[8
]}

Tseng, Po-Jung ^{[1
]}

Wu, Ming-Ying ^{[1
]}

Chien, Kuan-Chiao ^{[9
]}

Weaver, Edward M. ^{[10
]}

Lee, Fei-Peng ^{[11
]}

Lin, Chia-Mo ^{[12
,13
]}

Chen, Kuang-Chao ^{[14
]}

Chiang, Rayleigh Ping-Ying ^{[4
,7
,15
]}

机构：

[1] Fu Jen Catholic Univ, Sch Med, Coll Med, New Taipei City, Taiwan

[2] Mayo Clin, Ctr Sleep Med, Div Pulm Sleep & Crit Care Med, Rochester, MN USA

[3] Fu Jen Catholic Univ, Dept Life Sci, New Taipei City, Taiwan

[4] Shin Kong Mem Hosp, Dept Otolaryngol, Taipei 11120, Taiwan

[5] Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA

[6] Stanford Univ, Sch Med, Div Sleep Med, Stanford, CA 94305 USA

[7] Natl Taiwan Univ, INSIGHT Ctr, Sleep Technol Special Interest Grp, Taipei 10764, Taiwan

[8] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan

[9] Natl Taiwan Normal Univ, Dept Life Sci, Taipei, Taiwan

[10] Univ Washington, Sch Med, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA

[11] Taipei Med Univ, Sch Med, Wan Fang Hosp, Dept Otolaryngol, Taipei, Taiwan

[12] Shin Kong Mem Hosp, Sleep Ctr, Taipei 11120, Taiwan

[13] Shin Kong Mem Hosp, Dept Pulmonol & Crit Care Med, Taipei 11120, Taiwan

[14] Cheng Hsin Gen Hosp, Dept Otolaryngol, Taipei, Taiwan

[15] Fu Jen Catholic Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, New Taipei City, Taiwan

来源：

SLEEP MEDICINE REVIEWS | 2013年 / 17卷 / 02期

关键词：

Obstructive sleep apnea syndrome; Neuropathology; Vibration trauma; Hypoxia; Inflammation; Upper airway surgery; TOPICAL OROPHARYNGEAL ANESTHESIA; GENIOGLOSSUS MUSCLE RESPONSES; TERM INTERMITTENT HYPOXIA; ARM VIBRATION SYNDROME; OXIDATIVE STRESS; SUBSTANCE-P; SOFT PALATE; NEGATIVE-PRESSURE; PERCEPTION THRESHOLDS; ANATOMIC DISORDER;

D O I：

10.1016/j.smrv.2012.05.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that leads to significant morbidity and mortality without adequate treatment. Though much emphasis on the pathogenesis of OSAS has been placed on a narrow upper airway space and associated muscular factors, possible neuropathy of the upper airway has not been fully elucidated. Increasing peer reviewed evidence suggests involvement of neurologic lesions of the upper airway in OSAS patients. In this article, we review the etiology and pathophysiology of OSAS, the evidence and possible mechanisms leading to upper airway neuropathy, and the relationship between upper airway neuropathy and OSAS. Further studies should focus on the long term effects of the upper airway neuropathy as related to the duration and severity of snoring and or apnea, and also on the potential methods of prevention and management of the neuropathy in sleep disordered breathing. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：161 / 168

页数：8

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