Depression and Cognitive Impairment in Older Adults

被引：66

作者：

Weisenbach, Sara L. ^{[1
,3
]}

Boore, Laurie A. ^{[2
]}

Kales, Helen C. ^{[2
,3
,4
]}

机构：

[1] Univ Michigan, Dept Psychiat, Sch Med, Ann Arbor, MI 48105 USA

[2] Univ Michigan, Dept Psychiat, Sch Med, Ann Arbor, MI 48109 USA

[3] VA Ann Arbor Healthcare Syst, Geriatr Res Educ & Clin Ctr, Ann Arbor, MI USA

[4] VA Ann Arbor Healthcare Syst, Ctr Clin Management Res, Ann Arbor, MI USA

来源：

CURRENT PSYCHIATRY REPORTS | 2012年 / 14卷 / 04期

关键词：

Late life depression; LLD; Elderly; Cognition; Dementia; Neuropsychological abnormalities; Mechanisms of cognitive deficits; Interventions for cognitive impairment; Treatment resistance; PROBLEM-SOLVING THERAPY; LATE-LIFE DEPRESSION; LATE-ONSET; GERIATRIC DEPRESSION; FUNCTIONAL CONNECTIVITY; CORTICAL THICKNESS; ANTERIOR CINGULATE; PREFRONTAL CORTEX; MAJOR DEPRESSION; ELDERLY-PATIENTS;

D O I：

10.1007/s11920-012-0278-7

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Late life depression (LLD) is a heterogeneous illness with high rates of treatment resistance. Cognitive impairment is common in the context of LLD, and LLD may be a prodromal symptom and/or potentially a risk factor for dementia. This manuscript reviews the most recent research into the cognitive deficits associated with LLD and risk of conversion to dementia in the context of LLD. We discuss potential moderators and mediators of cognitive deficits in LLD, including demographic and clinical variables, in addition to brain structure and function. Potential interventions for cognitive symptoms of LLD are reviewed. We conclude with a discussion of the broader implications of what is now known about LLD, and how this might be applied toward improved prognosis and models for effective treatment.

引用

页码：280 / 288

页数：9

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