One-Pot Transformation of Carboxylic Acids into Nitriles

被引：18
|
作者：
Miyagi, Kotaro [1 ]
Moriyama, Katsuhiko [1 ]
Togo, Hideo [1 ]
机构：
[1] Chiba Univ, Grad Sch Sci, Chiba, Japan
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 26期
关键词：
Carboxylic acids; Cyanides; Iodine; Ammonia; One-pot reactions; DIRECT OXIDATIVE CONVERSION; ELECTRON-RICH AROMATICS; MOLECULAR-IODINE; PRIMARY AMIDES; PRIMARY AMINES; CATALYZED OXIDATION; FACILE PREPARATION; TERTIARY-AMINES; SYNTHETIC USE; ALCOHOLS;
D O I：
10.1002/ejoc.201300629
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with ethyl iodide/K2CO3/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminium hydride (SDBBA-H), and finally treatment with molecular iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. This method is useful for the conversion of various aromatic and aliphatic carboxylic acids into the corresponding nitriles in a one-pot procedure.
引用
收藏
页码：5886 / 5892
页数：7
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