Synthesis and evaluation of a 99mTc-labeled deoxyglucose derivative as a potential agent to target tumor

In this study, ethylene diamine tetraacetic acid-deoxyglucose (EDTADG) ligand was successfully synthesized and then radiolabeled with Tc-99m directly to produce Tc-99m-EDTADG with high radiochemical purity. Tc-99m-EDTADG showed good in vitro stability. The partition coefficient and electrophoresis results showed it was hydrophilic and negatively charged. The biodistribution study in mice bearing S180 tumor showed that Tc-99m-EDTADG had high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Single photon emission computed tomography imaging clearly visualized the tumor, suggesting it could be considered as a potential agent for tumor imaging.