Synthesis and evaluation of a 99mTc-labeled deoxyglucose derivative as a potential agent to target tumor

被引：5

作者：

Wang, Yue ^{[1
]}

Song, Xiaoqing ^{[1
]}

Zhang, Junbo ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2015年 / 306卷 / 02期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

D-glucose derivative; (99)mTc; SPECT; Tumor diagnosis; IMAGING AGENT; BIOLOGICAL EVALUATION; D-GLUCOSE; DITHIOCARBAMATE; BIODISTRIBUTION; COMPLEX; TC-99M-OXO; SPECT;

D O I：

10.1007/s10967-015-4109-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, ethylene diamine tetraacetic acid-deoxyglucose (EDTADG) ligand was successfully synthesized and then radiolabeled with Tc-99m directly to produce Tc-99m-EDTADG with high radiochemical purity. Tc-99m-EDTADG showed good in vitro stability. The partition coefficient and electrophoresis results showed it was hydrophilic and negatively charged. The biodistribution study in mice bearing S180 tumor showed that Tc-99m-EDTADG had high accumulation in tumor tissue with high tumor-to-muscle and tumor-to-blood ratios. Single photon emission computed tomography imaging clearly visualized the tumor, suggesting it could be considered as a potential agent for tumor imaging.

引用

页码：477 / 482

页数：6

共 50 条

[1] Synthesis and evaluation of a 99mTc-labeled deoxyglucose derivative as a potential agent to target tumor
Yue Wang
Xiaoqing Song
Junbo Zhang
Journal of Radioanalytical and Nuclear Chemistry, 2015, 306 : 477 - 482
[2] Development and evaluation of 99mTc-labeled LHRH peptide as potential tumor imaging agent
Camacho, Ximena
Cabrera, Mirel
Alfaya, Lucia
Garcia, Maria Fernanda
Lecot, Nicole
Fernandez, Marcelo
Gambini, Juan
Cabral, Pablo
JOURNAL OF NUCLEAR MEDICINE, 2017, 58
[3] Synthesis and evaluation of a 99mTc-labeled tubulin-binding agent for tumor imaging
Erfani, Mostafa
Shamsaei, Mojtaba
Mohammadbaghery, Faiyaz
Shirmardi, Seyed Pezhman
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2014, 57 (06): : 419 - 424
[4] Synthesis, Radiolabeling and Biological Evaluation of 99mTc-labeled Deoxyglucose Derivatives for Molecular Imaging
Sadeghzadeh, Masoud
Charkhlooiea, Ghorbanali
Daha, Fariba Johari
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2013, 12 (03): : 273 - 280
[5] Synthesis and preliminary biological evaluation of a 99mTc-labeled hypericin derivative as a necrosis avid imaging agent
Fonge, Humphrey
Jin, Lixin
Wang, Huaijun
Bormans, Guy
Ni, Yicheng
Verbruggen, Alfons
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2008, 51 (1-2): : 33 - 40
[6] A novel 99mTc-labeled testosterone derivative as a potential agent for targeting androgen receptors
Das, Tapas
Banerjee, Sharmila
Samuel, Grace
Bapat, Ketaki
Subramanian, Suresh
Pillai, Maroor R. A.
Venkatesh, Meera
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (22) : 5788 - 5792
[7] Evaluation of 99mTc-labeled Photosan-3, a hematoporphyrin derivative, as a potential radiopharmaceutical for tumor scintigraphy
Babbar, AK
Singh, AK
Goel, HC
Chauhan, UPS
Sharma, RK
NUCLEAR MEDICINE AND BIOLOGY, 2000, 27 (04) : 419 - 426
[8] Evaluation of 99mTc-labeled photosan-3, a hematoporphyrin derivative, as a potential radiopharmaceutical for tumor scintigraphy
Babbar, AK
Singh, AK
Goel, HC
Chauhan, UPS
Sharma, RK
NUCLEAR MEDICINE AND BIOLOGY, 2000, 27 (06) : 587 - 592
[9] Synthesis and preliminary biological evaluation of a 99mTc-labeled thymidine analog as a potential candidate for tumor imaging
Lu, ChunXiong
Jiang, Quanfu
JOURNAL OF NUCLEAR MEDICINE, 2011, 52
[10] Synthesis and Characterization of 99mTc-Labeled Peptides as a Potential Amyloid Plaques Imaging Agent
Sobral, D. V.
Miranda, A. C. C.
Barboza, M. F.
Marques, F. L. N.
Nakaie, C. R.
Malavolta, L.
BIOPOLYMERS, 2013, 100 (03) : 295 - 295

← 1 2 3 4 5 →