Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer

被引：30
|
作者：
Shimizu, Takahiro [1 ]
Marusawa, Hiroyuki [1 ]
Watanabe, Norihiko [1 ]
Chiba, Tsutomu [1 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sakyo Ku, Kyoto 6068507, Japan
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2015年 / 44卷 / 03期
关键词：
Gastric cancer; Helicobacter pylori; Inflammation; Genetics; Epigenetics; INDUCED CYTIDINE DEAMINASE; INFLAMMATION-ASSOCIATED CANCER; CLASS SWITCH RECOMBINATION; ABERRANT DNA METHYLATION; NECROSIS-FACTOR-ALPHA; EPITHELIAL-CELLS; INCREASED RISK; CAGA PROTEIN; SOMATIC MUTATIONS; INFECTION;
D O I：
10.1016/j.gtc.2015.05.011
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Helicobacter pylori infection plays a crucial role in gastric carcinogenesis. H pylori exerts oncogenic effects on gastric mucosa through complex interaction between bacterial virulence factors and host inflammatory responses. On the other hand, gastric cancer develops via stepwise accumulation of genetic and epigenetic alterations in H pylori-infected gastric mucosa. Recent comprehensive analyses of gastric cancer genomes indicate a multistep process of genetic alterations as well as possible molecular mechanisms of gastric carcinogenesis. Both genetic processes of gastric cancer development and molecular oncogenic pathways related to H pylori infection are important to completely understand the pathogenesis of H pylon-related gastric cancer.
引用
收藏
页码：625 / +
页数：15
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