Cyclophosphamide for CLL: to be or not CYP2B activated?

被引：2
|
作者：
Geisler, Christian H. [1 ]
机构：
[1] Rigshosp, Copenhagen, Denmark
来源：
BLOOD | 2013年 / 122卷 / 26期
关键词：
FLUDARABINE PLUS CYCLOPHOSPHAMIDE; CHRONIC LYMPHOCYTIC-LEUKEMIA; TRIAL;
D O I：
10.1182/blood-2013-10-534115
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Johnson et al1 report their findings of the hepatic cytochrome P450 (CYP) enzyme gene polymorphisms in patients with chronic lymphocytic leukemia (CLL) treated with fludarabine and cyclophosphamide (FC) within a clinical trial. Patients with at least one *6 allele had significantly lower rates of complete response and also less toxicity than patients with *1/*1 alleles, as well as a trend of shorter progression-free survival (PFS). Albeit indirect, this is the first indication in a controlled clinical trial of a significant impact of cyclophosphamide (CPA) bioactivation in CLL and a step toward tailored therapy of cancer. Copyright © 2011 by The American Society of Hematology; all rights reserved.
引用
收藏
页码：4156 / 4157
页数：2
相关论文
共 50 条
  • [21] Structure-activity study of CYP2B induction in rat liver
    Gulyaeva, Lyudmila F.
    Pustylnyak, Vladimir
    Yarushkin, Andrey
    Slynko, Nikolay
    DRUG METABOLISM REVIEWS, 2009, 41 : 43 - 44
  • [22] Dexamethasone Induction of Murine CYP2B Genes Requires the Glucocorticoid Receptor
    Audet-Walsh, Etienne
    Anderson, Alan
    DRUG METABOLISM AND DISPOSITION, 2009, 37 (03) : 580 - 588
  • [23] Ordered chimerogenesis applied to CYP2B P450 enzymes
    Lautier, Thomas
    Urban, Philippe
    Loeper, Jacqueline
    Jezequel, Laetitia
    Pompon, Denis
    Truan, Gilles
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2016, 1860 (07): : 1395 - 1403
  • [24] Expression and localization of the CYP2B subfamily predominantly in neurones of rat brain
    Rosenbrock, H
    Hagemeyer, CE
    Ditter, M
    Knoth, R
    Volk, B
    JOURNAL OF NEUROCHEMISTRY, 2001, 76 (02) : 332 - 340
  • [25] Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes
    Jacobs, JM
    Nichols, CE
    Andrew, AS
    Marek, DE
    Wood, SG
    Sinclair, PR
    Wrighton, SA
    Kostrubsky, VE
    Sinclair, JF
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1999, 157 (01) : 51 - 59
  • [26] CRYSTAL STRUCTURE OF CYP2B6 IN COMPLEX WITH AN EFAVIRENZ ANALOG: FROM PLASTICITY TO PI INTERACTIONS IN CYP2B ENZYMES
    Shah, Manish B.
    Halpert, James R.
    DRUG METABOLISM AND PHARMACOKINETICS, 2018, 33 (01) : S32 - S33
  • [27] Pituitary component of the aromatic hydrocarbon-mediated expression of CYP2B and CYP2C11
    Bergeron, RM
    Serron, SC
    Rinehart, JJ
    Cawley, GF
    Backes, WL
    XENOBIOTICA, 1998, 28 (03) : 303 - 312
  • [28] CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs
    Chirulli, V
    Longo, V
    Marini, S
    Mazzaccaro, A
    Fiorio, R
    Gervasi, PG
    LIFE SCIENCES, 2005, 76 (22) : 2535 - 2546
  • [29] Time course of CYP2B and CYP3A activities in freshly isolated human and animal hepatocytes
    Wright, K
    Fontenot, B
    Khan, KK
    Fisher, CW
    Black, C
    DRUG METABOLISM REVIEWS, 2003, 35 : 34 - 34
  • [30] AhR and PPARα:: antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11
    Shaban, Z
    Soliman, M
    El-Shazly, S
    El-Bohi, K
    Abdelazeez, A
    Kehelo, K
    Kim, HS
    Muzandu, K
    Ishizuka, M
    Kazusaka, A
    Fujita, S
    XENOBIOTICA, 2005, 35 (01) : 51 - 68
12345