Cyclophosphamide for CLL: to be or not CYP2B activated?

被引：2
|
作者：
Geisler, Christian H. [1 ]
机构：
[1] Rigshosp, Copenhagen, Denmark
来源：
BLOOD | 2013年 / 122卷 / 26期
关键词：
FLUDARABINE PLUS CYCLOPHOSPHAMIDE; CHRONIC LYMPHOCYTIC-LEUKEMIA; TRIAL;
D O I：
10.1182/blood-2013-10-534115
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Johnson et al1 report their findings of the hepatic cytochrome P450 (CYP) enzyme gene polymorphisms in patients with chronic lymphocytic leukemia (CLL) treated with fludarabine and cyclophosphamide (FC) within a clinical trial. Patients with at least one *6 allele had significantly lower rates of complete response and also less toxicity than patients with *1/*1 alleles, as well as a trend of shorter progression-free survival (PFS). Albeit indirect, this is the first indication in a controlled clinical trial of a significant impact of cyclophosphamide (CPA) bioactivation in CLL and a step toward tailored therapy of cancer. Copyright © 2011 by The American Society of Hematology; all rights reserved.
引用
收藏
页码：4156 / 4157
页数：2
相关论文
共 50 条
  • [1] On the mechanism of hepatocarcinogenesis of benzodiazepines: Evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice
    Parkinson, A
    Leonard, N
    Draper, A
    Ogilvie, BW
    DRUG METABOLISM REVIEWS, 2006, 38 (1-2) : 235 - 259
  • [2] Differential effects of oltipraz on CYP1A and CYP2B in rat lung
    Le Ferrec, E
    Ilyin, G
    Mahéo, K
    Bardiau, C
    Courtois, A
    Guillouzo, A
    Morel, F
    CARCINOGENESIS, 2001, 22 (01) : 49 - 55
  • [3] Ring hydroxylation of [o-H-3]Methoxychlor as a probe for liver microsomal CYP2B activity: Potential for in vivo CYP2B assay
    Stresser, DM
    Dehal, SS
    Kupfer, D
    ANALYTICAL BIOCHEMISTRY, 1996, 233 (01) : 100 - 107
  • [4] Plasticity of CYP2B Enzymes: Structural and Solution Biophysical Methods
    Wilderman, P. Ross
    Halpert, James R.
    CURRENT DRUG METABOLISM, 2012, 13 (02) : 167 - 176
  • [5] Induction of the CYP2B genes by triphenyldioxane treatment in the rat liver
    Grigorieva, E
    Soshilov, A
    Surovtseva, Y
    Schwartz, EL
    Duzhak, TG
    Gulyaeva, LF
    Lyakhovich, VV
    TOXICOLOGY IN VITRO, 2002, 16 (04) : 467 - 473
  • [6] Inhibition of rat hepatic microsomal CYP2B by resveratrol.
    Chang, TKH
    Ko, HH
    FASEB JOURNAL, 1999, 13 (05): : A811 - A811
  • [7] ROLE OF MICRORNA IN SPECIES-SPECIFIC INDUCTION OF CYP2B
    Gulyaeva, Lyudmila F.
    Kolmykov, Semen K.
    Chanyshev, Mikhail D.
    Krylova, Irina N.
    Nechkin, Sergey S.
    DRUG METABOLISM REVIEWS, 2015, 47 : 66 - 66
  • [8] REGULATION OF CYP2B GENE-EXPRESSION IN THE INTESTINAL MUCOSE
    ELIA, AP
    SHEPHARD, EA
    PHILLIPS, IR
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1994, 22 (02) : S123 - S123
  • [9] Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A
    Noskova, Kristyna
    Dovrtelova, Gabriela
    Zendulka, Ondrej
    Strakosova, Marketa
    Pes, Ondrej
    Jurica, Jan
    PHARMACOLOGICAL REPORTS, 2020, 72 (01) : 156 - 165
  • [10] CYP2C and CYP2B Mediated Metabolic Activation of Retrorsine in Cyp3a Knockout Mice
    Pang, Xiaoyan
    Tang, Chongzhuang
    Kong, Fandi
    Chen, Meixia
    Chen, Xiaoyan
    CURRENT DRUG METABOLISM, 2020, 21 (13) : 1040 - 1051
12345