A Rhodamine-Hydroxamic Acid-Based Fluorescent Probe for Hypochlorous Acid and Its Applications to Biological Imagings

被引：267
|
作者：
Yang, Young-Keun [1 ]
Cho, Hyungseoph Jason [1 ]
Lee, Jihyun [1 ]
Shin, Injae [1 ]
Tae, Jinsung [1 ]
机构：
[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 04期
关键词：
MYELOPEROXIDASE; CHLORAMINES; OXIDANT; IONS;
D O I：
10.1021/ol802822t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed. The system, which utilizes an irreversible HOCl-promoted oxidation reaction, responds instantaneously at room temperature with linear proportionality to the amount of HOCl. This system is highly selective for HOCl over other reactive oxygen species (ROS) and highly sensitive in aqueous solutions. Biological imaging studies using living cells and organisms (A549 cells and zebrafish) to detect HOCl are successfully demonstrated.
引用
收藏
页码：859 / 861
页数：3
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