The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11
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作者:
Chen, C.
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Albany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USAAlbany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA
Chen, C.
[1
]
Zhou, Z.
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Albany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USAAlbany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA
Zhou, Z.
[1
]
Liu, R.
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Albany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USAAlbany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA
Liu, R.
[1
]
Li, Y.
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Albany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USAAlbany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA
Li, Y.
[1
]
Azmi, P. B.
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Univ Toronto, Div Mol & Cellular Biol, Sunnybrook Res Inst, Toronto, ON, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, CanadaAlbany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA
Azmi, P. B.
[2
,3
]
Seth, A. K.
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Univ Toronto, Div Mol & Cellular Biol, Sunnybrook Res Inst, Toronto, ON, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, CanadaAlbany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA
Seth, A. K.
[2
,3
]
机构:
[1] Albany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA
[2] Univ Toronto, Div Mol & Cellular Biol, Sunnybrook Res Inst, Toronto, ON, Canada
[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
The WW domain containing E3 ubiquitin protein ligase 1 (WWP1) is a homologous to the E6-associated protein C terminus-type E3 ligase frequently overexpressed in human prostate and breast cancers due to gene amplification. Previous studies suggest that WWP1 promotes cell proliferation and survival; however, the mechanism of WWP1 action is still poorly understood. Here, we showed that WWP1 upregulates and maintains erythroblastic leukemia viral oncogene homolog 2 (ErbB2) and epithelial growth factor receptor (EGFR) in multiple cell lines. WWP1 depletion dramatically attenuates the EGF-induced ERK phosphorylation. WWP1 forms a protein complex with RING finger protein 11 (RNF11), a negative regulator of ErbB2 and EGFR. The protein protein interaction is through the first and third WW domains of WWP1 and the PY motif of RNF11. Although WWP1 is able to ubiquitinate RNF11 in vitro and in vivo, WWP1 neither targets RNF11 for degradation nor changes RNF11's cellular localization. Importantly, inhibition of RNF11 can rescue WWP1 siRNA-induced ErbB2 and EGFR downregulation and growth arrest. Finally, we demonstrated that RNF11 is overexpressed in a panel of prostate and breast cancer cell lines with WWP1 expression. These findings suggest that WWP1 may promote cell proliferation and survival partially through suppressing RNF11-mediated ErbB2 and EGFR downregulation. Oncogene (2008) 27, 6845-6855; doi: 10.1038/onc.2008.288; published online 25 August 2008
机构:
Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Basiorka, Ashley A.
McGraw, Kathy L.
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Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Canc Biol PhD Program, Tampa, FL USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
McGraw, Kathy L.
Griner, Lori N.
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Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Canc Biol PhD Program, Tampa, FL USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Griner, Lori N.
Zhang, Ling
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Zhang, Ling
De Ceuninck, Leentje
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Univ Ghent VIB, Dept Med Prot Res, B-9052 Ghent, BelgiumUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
De Ceuninck, Leentje
Caceres, Gisela
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Caceres, Gisela
Sokol, Lubomir
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Sokol, Lubomir
Komrokji, Rami S.
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Komrokji, Rami S.
Wei, Sheng
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Wei, Sheng
Tavernier, Jan
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Univ Ghent VIB, Dept Med Prot Res, B-9052 Ghent, BelgiumUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
Tavernier, Jan
List, Alan F.
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USAUniv S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
机构:
Kyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, Japan
Tokyo Womens Med Univ, Dept Pathol, Div Pathol Neurosci, Tokyo, JapanKyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, Japan
Watabe, Kazuhiko
Niida-Kawaguchi, Motoko
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Kyorin Univ, Fac Hlth Sci, Dept Clin Psychol, Tokyo, Japan
Tokyo Womens Med Univ, Dept Pathol, Div Pathol Neurosci, Tokyo, JapanKyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, Japan
Niida-Kawaguchi, Motoko
Tada, Mari
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Niigata Univ, Brain Res Inst, Dept Pathol, Niigata, JapanKyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, Japan
Tada, Mari
Kato, Yoichiro
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Tokyo Womens Med Univ, Dept Pathol, Div Pathol Neurosci, Tokyo, JapanKyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, Japan
Kato, Yoichiro
Murata, Makiko
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Kyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, JapanKyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, Japan
Murata, Makiko
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Tanji, Kunikazu
Wakabayashi, Koichi
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Hirosaki Univ, Inst Brain Sci, Dept Neuropathol, Grad Sch Med, Hirosaki, Aomori, JapanKyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, Japan
Wakabayashi, Koichi
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Yamada, Mitsunori
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Kakita, Akiyoshi
Shibata, Noriyuki
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Tokyo Womens Med Univ, Dept Pathol, Div Pathol Neurosci, Tokyo, JapanKyorin Univ, Fac Hlth Sci, Dept Med Technol Neuropathol, Tokyo, Japan
机构:
McLaughlin Res Inst, Great Falls, MT USAMcLaughlin Res Inst, Great Falls, MT USA
Silvius, Derek
Pitstick, Rose
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McLaughlin Res Inst, Great Falls, MT USAMcLaughlin Res Inst, Great Falls, MT USA
Pitstick, Rose
Ahn, Misol
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Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USAMcLaughlin Res Inst, Great Falls, MT USA
Ahn, Misol
Meishery, Delisha
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McLaughlin Res Inst, Great Falls, MT USAMcLaughlin Res Inst, Great Falls, MT USA
Meishery, Delisha
Oehler, Abby
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Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USAMcLaughlin Res Inst, Great Falls, MT USA
Oehler, Abby
Barsh, Gregory S.
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Stanford Univ, Dept Genet, Stanford, CA 94305 USA
Stanford Univ, Dept Pediat, Stanford, CA 94305 USAMcLaughlin Res Inst, Great Falls, MT USA
Barsh, Gregory S.
DeArmond, Stephen J.
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Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USAMcLaughlin Res Inst, Great Falls, MT USA
DeArmond, Stephen J.
Carlson, George A.
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McLaughlin Res Inst, Great Falls, MT USAMcLaughlin Res Inst, Great Falls, MT USA
Carlson, George A.
Gunn, Teresa M.
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McLaughlin Res Inst, Great Falls, MT USAMcLaughlin Res Inst, Great Falls, MT USA
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Univ Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USAUniv Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA
Jiang, Ji
Bellani, Marina
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NIA, Lab Mol Gerontol, NIH, Baltimore, MD 21224 USAUniv Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA
Bellani, Marina
Li, Lin
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Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USAUniv Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA
Li, Lin
Wang, Pengcheng
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Univ Calif Riverside, Environm Toxicol Grad Program, Riverside, CA 92521 USAUniv Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA
Wang, Pengcheng
Seidman, Michael M.
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NIA, Lab Mol Gerontol, NIH, Baltimore, MD 21224 USAUniv Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA
Seidman, Michael M.
Wang, Yinsheng
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Univ Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA
Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA
Univ Calif Riverside, Environm Toxicol Grad Program, Riverside, CA 92521 USAUniv Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA
机构:
Tsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R ChinaTsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China
Han, Yongqing
Li, Rong
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Tsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R ChinaTsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China
Li, Rong
Gao, Jinlan
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Tsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R ChinaTsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China
Gao, Jinlan
Miao, Shiying
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Tsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R ChinaTsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China
Miao, Shiying
Wang, Linfang
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Tsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R ChinaTsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China