Evaluating the preventive and curative effects ofToxocara canislarva in Freund's complete adjuvant-induced arthritis

Helminthic infection and the parallel host immune reactions are the results of a protracted dynamic co-interaction between the host and worms. An assessment of the effect ofToxocara canisinfection on arthritis in rats stimulated by Freund's complete adjuvant (FCA) was the main purpose of the investigation. An arthritis model was established by the administration of 0.1 mL FCA in the palmar surface. Cytokine assessment, evaluating oedema and the use of a rheumatoid arthritis (RA) score provided evidence of the protective effects ofT canisagainst adjuvant-induced arthritis (AIA). The cytokines TGF-beta, IFN-gamma, IL-10 and IL-17 were measured to assess the anti-inflammatory effect ofT canisinfection. Besides, arthritis swelling findings were evaluated in rat paws. The data showed thatT canisinfection significantly modulated the immune response by alleviating inflammatory cytokines and increasing TGF-beta as an anti-inflammatory cytokine. Evaluations of arthritis swelling showed low severity and faster recuperation. These findings suggest that the products derived fromT caniseggs might be a potential therapeutic candidate to treat autoimmune diseases like the arthritis.