Progression of Cortical Thinning in Early Parkinson's Disease

被引：99
|
作者：
Ibarretxe-Bilbao, Naroa [1 ,2 ,3 ,6 ]
Junque, Carme [1 ,2 ,3 ]
Segura, Barbara [1 ,2 ,3 ]
Baggio, Hugo C. [1 ,2 ,3 ]
Marti, Maria J. [1 ,2 ,4 ]
Valldeoriola, Francesc [1 ,2 ,4 ]
Bargallo, Nuria [2 ,5 ]
Tolosa, Eduardo [1 ,2 ,4 ]
机构：
[1] Hosp Clin Barcelona, Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Catalonia, Spain
[2] Inst Biomed Res August Pi i Sunyer, Catalonia, Spain
[3] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Catalonia, Spain
[4] Hosp Clin Barcelona, Inst Clin Neurociencies, Parkinsons Dis & Movement Disorders Unit, Neurol Serv, Catalonia, Spain
[5] Hosp Clin Barcelona, Ctr Diagnost Imatge, Catalonia, Spain
[6] Univ Deusto, Fac Psychol & Educ, Dept Methods & Expt Psychol, Bilbao, Spain
来源：
MOVEMENT DISORDERS | 2012年 / 27卷 / 14期
关键词：
Parkinson's disease; cognition; longitudinal; cortical thickness; VOXEL-BASED MORPHOMETRY; CLUSTER-SIZE INFERENCE; HUMAN CEREBRAL-CORTEX; GEOMETRICALLY ACCURATE; COGNITIVE IMPAIRMENT; PERMUTATION METHODS; BRAIN ATROPHY; RANDOM-FIELD; DEMENTIA; MRI;
D O I：
10.1002/mds.25240
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean +/- standard deviation = 35.50 +/- 1.88 months) in a group of 16 early-PD patients (H & Y stage <= II and disease duration <= 5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process. (C) 2012 Movement Disorder Society
引用
收藏
页码：1746 / 1754
页数：9
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