Drugging the Undruggable: Small-Molecule Inhibition of the Ras Oncoprotein

被引:0
|
作者
Maurer, T. [1 ]
Garrenton, L. [1 ]
Oh, A. [1 ]
Pitts, K. [1 ]
Skelton, N. [1 ]
Fauber, B. [1 ]
Pan, B. [1 ]
Malek, S. [1 ]
Stokoe, D. [1 ]
Bowman, K. [1 ]
Wu, J. [1 ]
Giannetti, A. [1 ]
Starovasnik, M. [1 ]
Mellman, I. [1 ]
Jackson, P. [1 ]
Rudolph, J. [1 ]
Wang, W. [1 ]
Fang, G. [1 ]
机构
[1] Genentech Inc, San Francisco, CA 94080 USA
关键词
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
24
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Novel treatment strategy for pancreatic cancer by targeting the 'undruggable' Ras oncoprotein
    Kano, Yoshihito
    Bunda, Severa
    Yeh, Jen Jen
    Zhang, Zhong-Yin
    Ohh, Michael
    CANCER RESEARCH, 2016, 76
  • [22] Proteasome-Independent Protein Knockdown by Small-Molecule Inhibitor for the Undruggable Lung Adenocarcinoma
    Zhou, Wei
    Sun, Guogui
    Zhang, Zhen
    Zhao, Libo
    Xu, Li
    Yuan, Hongyu
    Li, Shumu
    Dong, Zaizai
    Song, Yongmei
    Fang, Xiaohong
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (46) : 18492 - 18499
  • [23] Small-Molecule Inhibition of Viral Fusion Glycoproteins
    Liu, Han-Yuan
    Yang, Priscilla L.
    ANNUAL REVIEW OF VIROLOGY, VOL 8, 2021, 8 : 459 - 489
  • [24] Small-molecule inhibition of inflammatory β-cell death
    Lundh, M.
    Scully, S. S.
    Mandrup-Poulsen, T.
    Wagner, B. K.
    DIABETES OBESITY & METABOLISM, 2013, 15 : 176 - 184
  • [25] Small-Molecule Inhibition of BRDT for Male Contraception
    Matzuk, Martin M.
    McKeown, Michael R.
    Filippakopoulos, Panagis
    Li, Qinglei
    Ma, Lang
    Agno, Julio E.
    Lemieux, Madeleine E.
    Picaud, Sarah
    Yu, Richard N.
    Qi, Jun
    Knapp, Stefan
    Bradner, James E.
    CELL, 2012, 150 (04) : 673 - 684
  • [26] Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3
    Song, Xianzhou
    Chen, Jianwei
    Zhao, Mingkun
    Zhang, Chengwei
    Yu, Yang
    Lonard, David M.
    Chow, Dar-Chone
    Palzkill, Timothy
    Xu, Jianming
    O'Malley, Bert W.
    Wang, Jin
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (18) : 4970 - 4975
  • [27] Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
    Anasuya Chattopadhyay
    Cornelius J. O’Connor
    Fengzhi Zhang
    Celine Galvagnion
    Warren R. J. D. Galloway
    Yaw Sing Tan
    Jamie E. Stokes
    Taufiq Rahman
    Chandra Verma
    David R. Spring
    Laura S. Itzhaki
    Scientific Reports, 6
  • [28] Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
    Chattopadhyay, Anasuya
    O'Connor, Cornelius J.
    Zhang, Fengzhi
    Galvagnion, Celine
    Galloway, Warren R. J. D.
    Tan, Yaw Sing
    Stokes, Jamie E.
    Rahman, Taufiq
    Verma, Chandra
    Spring, David R.
    Itzhaki, Laura S.
    SCIENTIFIC REPORTS, 2016, 6
  • [29] Inhibition of a viral enzyme by a small-molecule dimer disruptor
    Shahian, Tina
    Lee, Gregory M.
    Lazic, Ana
    Arnold, Leggy A.
    Velusamy, Priya
    Roels, Christina M.
    Guy, R. Kiplin
    Craik, Charles S.
    NATURE CHEMICAL BIOLOGY, 2009, 5 (09) : 640 - 646
  • [30] Small-molecule inhibition of HIV-1 Vif
    Nathans, Robin
    Cao, Hong
    Sharova, Natalia
    Ali, Akbar
    Sharkey, Mark
    Stranska, Ruzena
    Stevenson, Mario
    Rana, Tariq M.
    NATURE BIOTECHNOLOGY, 2008, 26 (10) : 1187 - 1192