Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

被引:24
|
作者
Lamichhane, Santosh [1 ,2 ]
Ahonen, Linda [3 ]
Dyrlund, Thomas Sparholt [3 ]
Dickens, Alex M. [1 ,2 ]
Siljander, Heli [4 ,5 ]
Hyoty, Heikki [6 ,7 ]
Ilonen, Jorma [8 ,9 ]
Toppari, Jorma [10 ,11 ]
Veijola, Riitta [12 ,13 ,14 ]
Hyotylainen, Tuulia [15 ]
Knip, Mikael [4 ,5 ,16 ,17 ]
Oresic, Matej [1 ,2 ,18 ]
机构
[1] Univ Turku, Turku Ctr Biotechnol, FIN-20520 Turku, Finland
[2] Abo Akad Univ, FIN-20520 Turku, Finland
[3] Steno Diabet Ctr Copenhagen, DK-2820 Gentofte, Denmark
[4] Univ Helsinki, Helsinki Univ Hosp, Childrens Hosp, FIN-00290 Helsinki, Finland
[5] Univ Helsinki, Res Program Unit, Diabet & Obes, FIN-00290 Helsinki, Finland
[6] Univ Tampere, Fac Med & Life Sci, Tampere 33014, Finland
[7] Pirkanmaa Hosp Dist, Fimlab Labs, Tampere 33014, Finland
[8] Univ Turku, Inst Biomed, Immunogenet Lab, FIN-20520 Turku, Finland
[9] Turku Univ Hosp, Clin Microbiol, Turku 20014, Finland
[10] Univ Turku, Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku 20014, Finland
[11] Turku Univ Hosp, Dept Pediat, Turku 20521, Finland
[12] Univ Oulu, Med Res Ctr, Dept Pediat, PEDEGO Res Unit, Oulu 90014, Finland
[13] Oulu Univ Hosp, Dept Children & Adolescents, Oulu 90220, Finland
[14] Karolinska Inst, Dept Womens & Childrens Hlth, S-17177 Stockholm, Sweden
[15] Orebro Univ, Sch Sci & Technol, S-70281 Orebro, Sweden
[16] Tampere Univ Hosp, Tampere Ctr Child Hlth Res, Tampere 33520, Finland
[17] Folkhalsan Res Ctr, Helsinki 00290, Finland
[18] Orebro Univ, Sch Med Sci, S-70281 Orebro, Sweden
来源
BIOMOLECULES | 2019年 / 9卷 / 01期
基金
芬兰科学院;
关键词
type; 1; diabetes; cord blood; lipidomics; metabolomics; autoimmunity; METABOLISM; PHOSPHATIDYLCHOLINE; DISCOVERY;
D O I
10.3390/biom9010033
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Increased Inflammation Is Associated With Islet Autoimmunity and Type 1 Diabetes in the Diabetes Autoimmunity Study in the Young (DAISY)
    Waugh, Kathleen C.
    Snell-Bergeon, Janet K.
    Dong, Fran
    Taki, Iman
    Hoffman, Michelle
    Rewers, Marian J.
    DIABETES, 2013, 62 : A419 - A419
  • [42] Height growth velocity, islet autoimmunity and type 1 diabetes development: the Diabetes Autoimmunity Study in the Young
    M. M. Lamb
    X. Yin
    G. O. Zerbe
    G. J. Klingensmith
    D. Dabelea
    T. E. Fingerlin
    M. Rewers
    J. M. Norris
    Diabetologia, 2009, 52 : 2064 - 2071
  • [43] Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY)
    Waugh, Kathleen
    Snell-Bergeon, Janet
    Michels, Aaron
    Dong, Fran
    Steck, Andrea K.
    Frohnert, Brigitte I.
    Norris, Jill M.
    Rewers, Marian
    PLOS ONE, 2017, 12 (04):
  • [44] Association Between Vitamin D Metabolism Gene Polymorphisms and Risk of Islet Autoimmunity and Progression to Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young (DAISY)
    Frederiksen, Brittni N.
    Kroehl, Miranda
    Fingerlin, Tasha E.
    Wong, Randall
    Steck, Andrea K.
    Rewers, Marian
    Norris, Jill M.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (11): : E1845 - E1851
  • [45] Height growth velocity, islet autoimmunity and type 1 diabetes development: the Diabetes Autoimmunity Study in the Young
    Lamb, M. M.
    Yin, X.
    Zerbe, G. O.
    Klingensmith, G. J.
    Dabelea, D.
    Fingerlin, T. E.
    Rewers, M.
    Norris, J. M.
    DIABETOLOGIA, 2009, 52 (10) : 2064 - 2071
  • [46] Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Stene, Lars C.
    Barriga, Katherine
    Hoffman, Michelle
    Kean, Jaime
    Klingensmith, Georgeanna
    Norris, Jill M.
    Erlich, Henry A.
    Eisenbarth, George S.
    Rewers, Marian
    PEDIATRIC DIABETES, 2006, 7 (05) : 247 - 253
  • [47] Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes
    Isaac V. Snowhite
    Gloria Allende
    Jay Sosenko
    Ricardo L. Pastori
    Shari Messinger Cayetano
    Alberto Pugliese
    Diabetologia, 2017, 60 : 1409 - 1422
  • [48] Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes
    Snowhite, Isaac V.
    Allende, Gloria
    Sosenko, Jay
    Pastori, Ricardo L.
    Cayetano, Shari Messinger
    Pugliese, Alberto
    DIABETOLOGIA, 2017, 60 (08) : 1409 - 1422
  • [49] Risk of Islet and Celiac Autoimmunity in Cotwins of Probands With Type 1 Diabetes
    Triolo, Taylor M.
    Pyle, Laura
    Seligova, Sona
    Yu, Liping
    Gottlieb, Peter A.
    Steck, Andrea K.
    JOURNAL OF THE ENDOCRINE SOCIETY, 2020, 4 (06)
  • [50] miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes
    Scherm, Martin G.
    Daniel, Carolin
    CURRENT DIABETES REPORTS, 2020, 20 (09)