Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders

被引：38
|
作者：
Agarwal, Shradha [1 ]
Cunningham-Rundles, Charlotte [1 ]
机构：
[1] Icahn Sch Med Mt Sinai, Div Allergy & Clin Immunol, One Gustave L Levy Pl,Box 1089, New York, NY 10029 USA
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2019年 / 39卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Primary immunodeficiency disorder; Gastrointestinal tract; Inflammatory bowel disease; Intestinal disease; Chronic enteropathy; Diarrhea; COMMON VARIABLE IMMUNODEFICIENCY; CHRONIC GRANULOMATOUS-DISEASE; INFLAMMATORY-BOWEL-DISEASE; HYPER-IGM SYNDROME; X-LINKED AGAMMAGLOBULINEMIA; STEM-CELL TRANSPLANTATION; NODULAR LYMPHOID HYPERPLASIA; IMMUNOGLOBULIN-A DEFICIENCY; BONE-MARROW-TRANSPLANTATION; REGULATORY T-CELLS;
D O I：
10.1016/j.iac.2018.08.006
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Gastrointestinal (GI) involvement can be the presenting disease manifestation in patients with primary immunodeficiency. Diarrhea both infections and non-infectious is the most frequent manifestation, but malignancy, inflammatory and autoimmune related GI diseases are also described. GI symptoms and pathology seen in association with PID can mimic other disease, such as celiac sprue and IBD but, are often resistant to conventional treatments owing to alternate disease mechanisms. Despite the advances in treatments for these inflammatory conditions, therapy for immunodeficiency related GI disease is often empiric.
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页码：81 / +
页数：15
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