Actin in hair cells and hearing loss

被引：51
|
作者：
Drummond, Meghan C. [1 ]
Belyantseva, Inna A. [1 ]
Friderici, Karen H. [2 ]
Friedman, Thomas B. [1 ]
机构：
[1] Natl Inst Deafness & Other Commun Disorders, Mol Genet Lab, NIH, Rockville, MD 20850 USA
[2] Michigan State Univ, Dept Microbiol & Mol Genet, Dept Pediat & Human Dev, E Lansing, MI 48824 USA
来源：
HEARING RESEARCH | 2012年 / 288卷 / 1-2期
关键词：
NONSYNDROMIC RECESSIVE DEAFNESS; GENOTYPE-PHENOTYPE CORRELATION; CYTOPLASMIC GAMMA-ACTIN; USHER-SYNDROME PROTEINS; MYOSIN-VIIA GENE; BETA-ACTIN; INNER-EAR; AUTOSOMAL-DOMINANT; UNCONVENTIONAL MYOSIN; TIP-LINK;
D O I：
10.1016/j.heares.2011.12.003
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Hereditary deafness is genetically heterogeneous such that mutations of many different genes can cause hearing loss. This review focuses on the evidence and implications that several of these deafness genes encode actin-interacting proteins or actin itself. There is a growing appreciation of the contribution of the actin interactome in stereocilia development, maintenance, mechanotransduction and malfunction of the auditory system. Published by Elsevier B.V.
引用
收藏
页码：89 / 99
页数：11
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