Synthesis and antihepatotoxic activity of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-substituted-phenyl-4,5-dihydro-1H-pyrazole derivatives

被引：39

作者：

Khalilullah, Habibullah ^{[1
,2
]}

Khan, Shamshir ^{[2
]}

Ahsan, Mohamed Jawed ^{[1
]}

Ahmed, Bahar ^{[2
]}

机构：

[1] Alwar Pharm Coll, Dept Pharmaceut Chem, Alwar 301030, Rajasthan, India

[2] Hamdard Univ, Fac Pharm, Antihepatotox Res Lab, New Delhi 110062, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 24期

关键词：

1,4-Benzodioxane; Pyrazoline; Antihepatotoxic activity; HERBAL FORMULATION;

D O I：

10.1016/j.bmcl.2011.10.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In continuance of our search for newer antihepatotoxic agents some novel pyrazoline derivatives containing 1,4-dioxane ring system were synthesized starting from 3-(2,3-dihydro-1,4-benzodioxane-6-yl)-1-substituted-phenylprop-2-en-1-one. Some of the synthesized compounds were evaluated for antihepatotoxic activity against CCl4-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：7251 / 7254

页数：4

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