Synthesis and antihepatotoxic activity of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-substituted-phenyl-4,5-dihydro-1H-pyrazole derivatives

被引：39
|
作者：
Khalilullah, Habibullah [1 ,2 ]
Khan, Shamshir [2 ]
Ahsan, Mohamed Jawed [1 ]
Ahmed, Bahar [2 ]
机构：
[1] Alwar Pharm Coll, Dept Pharmaceut Chem, Alwar 301030, Rajasthan, India
[2] Hamdard Univ, Fac Pharm, Antihepatotox Res Lab, New Delhi 110062, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 24期
关键词：
1,4-Benzodioxane; Pyrazoline; Antihepatotoxic activity; HERBAL FORMULATION;
D O I：
10.1016/j.bmcl.2011.10.056
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In continuance of our search for newer antihepatotoxic agents some novel pyrazoline derivatives containing 1,4-dioxane ring system were synthesized starting from 3-(2,3-dihydro-1,4-benzodioxane-6-yl)-1-substituted-phenylprop-2-en-1-one. Some of the synthesized compounds were evaluated for antihepatotoxic activity against CCl4-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin. (C) 2011 Elsevier Ltd. All rights reserved.
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收藏
页码：7251 / 7254
页数：4
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