The importance of culling in Johne's disease control

被引:76
|
作者
Lu, Z. [1 ]
Mitchell, R. M. [1 ]
Smith, R. L. [1 ]
Van Kessel, J. S. [2 ]
Chapagain, P. P. [1 ,3 ]
Schukken, Y. H. [1 ]
Grohn, Y. T. [1 ]
机构
[1] Cornell Univ, Dept Populat Med & Diagnost Sci, Coll Vet Med, Ithaca, NY 14853 USA
[2] ARS, Environm Microbial Safety Lab, USDA, Beltsville, MD USA
[3] Florida Int Univ, Dept Phys, Miami, FL 33199 USA
关键词
Johne's disease; culling; test sensitivity; phase diagram; basic reproduction ratio;
D O I
10.1016/j.jtbi.2008.05.008
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Johne's disease is caused by Mycobacterium avium subsp. paratuberculosis (MAP) infection and results in economic losses in the dairy industry. To control MAP transmission in herds, test-based culling has been recommended and immediate culling of high shedding animals is typically implemented. In this study, we quantified the effects of MAP control in US dairy herds, using the basic reproduction ratio R-0. The effectiveness of culling strategies was evaluated for good and poor herd management (low- and high-transmission rates, respectively) by a phase diagram approach. To establish a quantitative relationship between culling rates and test properties, we defined the average detection times for low and high shedding animals. The effects of various culling strategies and test characteristics, such as test sensitivity, test turnaround time, and testing interval, were analyzed. To understand the overall effect of model parameters on R-0, we performed global uncertainty and sensitivity analyses. We also evaluated the effectiveness of culling only high shedding animals by comparing three test methods (fecal culture, fecal polymerase chain reaction, PCR, and enzyme-linked immunosorbent assay, ELISA). Our study shows that, in the case of good herd management, culling of only high shedding animals may be effective in controlling MAP transmission. However, in the case of poor management, in addition to immediate culling of high shedding animals, culling of low shedding animals (based on the fecal culture test) will be necessary. Culling of low shedding animals may be delayed 6-12 months, however, if a shorter testing interval is applied. This study suggests that if farmers prefer culling only high shedding animals, faster MAP detection tests (such as the fecal PCR and ELISA) of higher sensitivity should be applied with high testing frequency, particularly on farms with poor management. Culling of infectious animals with a longer testing interval is generally not effective to control MAP. (C) 2008 Elsevier Ltd. Ail rights reserved.
引用
收藏
页码:135 / 146
页数:12
相关论文
共 50 条
  • [41] Tackling Johne's disease
    不详
    VETERINARY RECORD, 2023, 193 (05) : 192 - 192
  • [42] Ovine Johne's disease
    Davies, HL
    AUSTRALIAN VETERINARY JOURNAL, 1997, 75 (11) : 799 - 799
  • [43] Approaches to Johne's disease
    Orpin, Peter
    Sibley, Richard
    VETERINARY RECORD, 2009, 164 (10) : 311 - 311
  • [44] Practical experiences in using disease data to promote farmer and vet engagement in Johne's Disease control - The development and impact of the Johne's Tracker
    Hanks, J.
    Orpin, P.
    Taylor, E.
    Morrison, R.
    CATTLE PRACTICE, 2023, 31 (01) : 14 - 15
  • [45] Economic evaluation of participation in a voluntary Johne's disease prevention and control program from a farmer's perspective-The Alberta Johne's Disease Initiative
    Wolf, R.
    Clement, F.
    Barkema, H. W.
    Orsel, K.
    JOURNAL OF DAIRY SCIENCE, 2014, 97 (05) : 2822 - 2834
  • [46] Johne's Disease Preface
    Collins, Michael T.
    VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 2011, 27 (03) : XI - XII
  • [47] Control of ovine Johne's disease in New South Wales (Australia)
    Denholm, LJ
    Ottaway, SJ
    Marshall, DJ
    FIFTH INTERNATIONAL COLLOQUIUM ON PARATUBERCULOSIS: MEETING OF THE INTERNATIONAL ASSOCIATION FOR PARATUBERCULOSIS, 1997, : 159 - 167
  • [48] Where are we with Johne's disease control - Can we eliminate?
    Wells, Scott J.
    PROCEEDINGS OF THE FORTIETH ANNUAL CONFERENCE AMERICAN ASSOCIATION OF BOVINE PRACTITIONERS, 2007, : 122 - 125
  • [49] The control and possible eradication of Johne's disease in a beef suckler herd
    Cutler, K. L.
    CATTLE PRACTICE, 2017, 25 : 146 - 148
  • [50] Control of paratuberculosis (Johne's disease) in goats by vaccination of adult animals
    Corpa, JM
    Pérez, V
    Sánchez, MA
    Marín, JFG
    VETERINARY RECORD, 2000, 146 (07) : 195 - 196