Acenocoumarol as an alternative anticoagulant in a patient with warfarin-related nephropathy

被引：5

作者：

Behera, Sapan Kumar ^{[1
]}

Xavier, Alphienes Stanley ^{[1
]}

Selvarajan, Sandhiya ^{[1
]}

Munuswamy, Hemachandren ^{[2
]}

Haridasan, Satish ^{[3
]}

Srinivas, Bheemanathi Hanuman ^{[4
]}

机构：

[1] JIPMER, Dept Clin Pharmacol, Pondicherry 605006, India

[2] JIPMER, Dept Cardiothorac & Vasc Surg, Pondicherry, India

[3] JIPMER, Dept Nephrol, Pondicherry, India

[4] JIPMER, Dept Pathol, Pondicherry, India

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2018年 / 84卷 / 05期

关键词：

D O I：

10.1111/bcp.13541

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adverse EventWarfarin-related nephropathy. Drug ImplicatedWarfarin. The PatientA 31-year-old female, managed with warfarin for rheumatic heart disease with atrial fibrillation. Evidence that Links the Drug to the EventThere were no alternative causes of nephropathy that could have caused the adverse event in this patient. ManagementShifting the drug from warfarin to acenocoumarol. MechanismDifference in renal elimination between warfarin and acenocoumarol. Implication for TherapyClinicians should be aware of this rare adverse effect of warfarin, and acenocoumarol can be considered as an alternative therapy for this condition. Hypotheses to be TestedFurther prospectively designed studies are needed to consider acenocoumarol as an alternative therapy in warfarin-related nephropathy.

引用

页码：1068 / 1071

页数：4

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