Using terahertz time-domain spectroscopy to identify pharmaceutical cocrystals

被引：0
|
作者：
Parrott, Edward P. J. [1 ,2 ]
Nguyen, K. Lien [1 ]
Friscic, Tomislav [3 ]
Zeitler, J. Axel [1 ]
Pepper, Michael [2 ,4 ]
Jones, William [3 ]
Gladden, Lynn F. [1 ]
机构：
[1] Univ Cambridge, Dept Chem Engn, Pembroke St, Cambridge CB2 3RA, England
[2] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England
[3] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[4] Teraview Ltd, Cambridge CB4 0WS, England
来源：
2007 JOINT 32ND INTERNATIONAL CONFERENCE ON INFRARED AND MILLIMETER WAVES AND 15TH INTERNATIONAL CONFERENCE ON TERAHERTZ ELECTRONICS, VOLS 1 AND 2 | 2007年
关键词：
D O I：
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中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
The conversion of polycrystalline pharmaceutical materials into their cocrystals has been monitored using terahertz (THz) spectroscopy. Eight cocrystal systems have been studied and their THz spectra were found to exhibit differences from the constituent materials. Cocrystals of theophylline and DL and L forms of malic acid were clearly differentiated using THz spectroscopy while powder X-ray diffraction (PXRD) results were less conclusive.
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页码：645 / +
页数：2
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