Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy

被引：132

作者：

Makhseed, Saad ^{[1
]}

Machacek, Miloslav ^{[2
]}

Alfadly, Waleed ^{[1
]}

Tuhl, Ahmad ^{[1
]}

Vinodh, Mickey ^{[1
]}

Simunek, Tomas ^{[2
]}

Novakova, Veronika ^{[3
]}

Kubat, Pavel ^{[4
]}

Rudolf, Emil ^{[5
]}

Zimcik, Petr ^{[6
]}

机构：

[1] Kuwait Univ, Dept Chem, Safat 13060, Kuwait

[2] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Biochem Sci, Hradec Kralove 50005, Czech Republic

[3] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Biophys & Phys Chem, Hradec Kralove 50005, Czech Republic

[4] Acad Sci Czech Republic, J Heyrovsky Inst Phys Chem, Vvi, CR-18223 Prague 8, Czech Republic

[5] Charles Univ Prague, Fac Med Hradec Kralove, Dept Med Biol & Genet, Hradec Kralove 50005, Czech Republic

[6] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Pharmaceut Chem & Drug Control, Hradec Kralove 50005, Czech Republic

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 95期

关键词：

PHOTOSENSITIZERS; SUBSTITUENTS;

D O I：

10.1039/c3cc44609c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Newly synthesized zinc phthalocyanine bearing sixteen quaternized imidazolyl moieties on the periphery displays high water-solubility, lack of aggregation and high singlet oxygen quantumyield inwater (Phi(Delta) > 0.33). The in vitro tests indicated excellent anticancer photodynamic activity (EC50 = 36.7 nM) and low dark toxicity to non-cancerous cells (TC50 = 395 mu M).

引用

页码：11149 / 11151

页数：3

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