An efficient Ir(III) catalyst for the asymmetric transfer hydrogenation of ketones in neat water

被引：56

作者：

Li, Xiaohong

Blacker, John

Houson, Ian

Wu, Xiaofeng

Xiao, Jianliang ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool Ctr Mat & Catalysis, Liverpool L69 7ZD, Merseyside, England

[2] NPIL Pharma, Huddersfield HD2 1GA, W Yorkshire, England

来源：

SYNLETT | 2006年 / 08期

关键词：

asymmetric transfer hydrogenation; ketones; water; formate; camphor ligand;

D O I：

10.1055/s-2006.932490

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chiral M-CsDPEN [M = Ru, Rh, Ir; CsDPEN = (R,R,R)- or (S,S,S)-N-camphorsulfonyl-1,2-diphenylethylenediamine] catalysts have been shown to be efficient for the asymmetric transfer hydrogenation (ATH) of aryl ketones by formate in neat water. Of particular note is the Ir-(R,R,R)-CsDPEN catalyst, which catalyzes the ATH of a wide range of ketones and delivers almost full conversions within a few hours at a S/C ratio of 1000 at 40 degrees C in most cases, with enantioselectivities up to 98% ee.

引用

页码：1155 / 1160

页数：6

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