Rearranged limonoids and chromones from Harrisonia perforata and their anti-inflammatory activity

被引：33
|
作者：
Choodej, Siwattra [1 ]
Sommit, Damrong [2 ]
Pudhom, Khanitha [1 ]
机构：
[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand
[2] Mahanakorn Univ Technol, Fac Sci, Dept Chem, Bangkok 10530, Thailand
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 13期
关键词：
Harrisonia perforata; Rearranged limonoid; Chromone; Anti-inflammatory; NF-KAPPA-B; CYTOKINES;
D O I：
10.1016/j.bmcl.2013.04.064
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new rearranged limonoids, harperforatin (1) and harperfolide (2), and a new chromone, harperamone (3), were isolated from fruits and roots of Harrisonia perforata, together with eight known compounds. Their structures were elucidated on the basis of spectroscopic data. Harperfolide (2) exhibited potent anti-inflammatory activity by suppressing nitric oxide (NO) production from activated macrophages with IC50 value of 6.51 mu M. Furthermore, its effect is mediated by reduction of iNOS protein expression, attributable to the inhibitory action of LPS-induced NO production. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3896 / 3900
页数：5
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