NPY mediates reward activity of morphine, via NPY Y1 receptors, in the nucleus accumbens shell

被引:31
|
作者
Desai, Sagar J. [1 ]
Upadhya, Manoj A. [1 ]
Subhedar, Nishikant K. [2 ]
Kokare, Dadasaheb M. [1 ]
机构
[1] Rashtrasant Tukadoji Maharaj Nagpur Univ Campus, Dept Pharmaceut Sci, Nagpur 440033, Maharashtra, India
[2] IISER, Pune 411021, Maharashtra, India
关键词
Opioids; Neuropeptide Y; Operant conditioning chamber; Brain stimulation reward; Nucleus accumbens shell; Immunohistochemistry; VENTRAL TEGMENTAL AREA; NEUROPEPTIDE YY1 RECEPTOR; BRAIN-STIMULATION REWARD; SELF-STIMULATION; CONTAINING NEURONS; RAT; WITHDRAWAL; NALOXONE; DOPAMINE; SYSTEM;
D O I
10.1016/j.bbr.2013.03.018
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Although the interaction between endogenous neuropeptide Y (NPY) and opioidergic systems in processing of reward has been speculated, experimental evidence is lacking. We investigated the role of NPY, and its Y1 receptors, in the nucleus accumbens shell (AcbSh) in morphine induced reward and reinforcement behavior. Rats were implanted with cannulae targeted at AcbSh for drug administration, and with stimulating electrode in the medial forebrain bundle (MFB). The rats were then conditioned in an operant conditioning chamber for electrical self-stimulation of the MFB. Increased rate of lever pressings was evaluated against the frequency of the stimulating current. Increase in rate of lever presses was considered as a measure of reward and reinforcement. About 30-70% increase in self-stimulation was observed following bilateral intra-AcbSh treatment with morphine, NPY or [Leu(31), Pro(34)]-NPY (NPY Y1/Y5 receptors agonist), however, BIBP3226 (selective NPY Y1 receptors antagonist) produced opposite effect. The reward effect of morphine was significantly potentiated by NPY or [Leu(31), Pro(34)]-NPY, but antagonized by BIBP3226. NPY-immunoreactivity in the AcbSh, arcuate nucleus (ARC) and lateral part of bed nucleus of stria terminalis (BNSTI) was significantly more in the operant conditioned rats than in naive control. However, morphine administration to the conditioned rats resulted in significant decrease in the NPY-immunoreactivity in all these anatomical regions. Since the role of morphine in modulation of mesolimbic-dopaminergic pathway is well established, we suggest that NPY system in AcbSh, ARC and BNST1, perhaps acting via Y1-receptor system, may be an important component of the mesolimbic-AcbSh reward circuitry triggered by endogenous opioids. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:79 / 91
页数:13
相关论文
共 50 条
  • [41] RECOMBINANTLY EXPRESSED Y1 RECEPTORS FOR NPY - DISTINCT SEQUENCE ELEMENTS CONTROL G-PROTEIN ACTIVATION
    ORKILD, H
    GETHER, U
    SHEIKH, SP
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S55 - S55
  • [42] 猪NPY受体Y1 cDNA的克隆及分析
    周春宝
    倪黎纲
    丁家桐
    包文斌
    安徽农业科学, 2008, 36 (36) : 15797 - 15798
  • [43] NPY Revealed as a Critical Modulator of Osteoblast Function In Vitro: New Insights Into the Role of Y1 and Y2 Receptors
    Teixeira, Liliana
    Sousa, Daniela M.
    Nunes, Ana Filipa
    Sousa, Monica M.
    Herzog, Herbert
    Lamghari, Meriem
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 107 (05) : 908 - 916
  • [44] Hypoxic Remodeling of Fetal Cerebral Arteries Involves The NPY/Y1 Pathway
    Adeoye, Olayemi
    Silpanisong, Jinjutha
    Kim, Dahlim
    Williams, James
    Pearce, William
    FASEB JOURNAL, 2015, 29
  • [45] NEUROPEPTIDE Y IN THE NUCLEUS ACCUMBENS CORE MODULATES ETHANOL-INDUCED LOCOMOTOR ACTIVITY: A ROLE FOR THE NPY Y2 RECEPTOR
    Hayes, D. M.
    McCown, T. J.
    Knapp, D. J.
    Breese, G. R.
    Thiele, T. E.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2009, 33 (06) : 145A - 145A
  • [46] Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists
    Sun, Zhong-Yue
    Zhu, Zhaoning
    Ye, Yuanzan
    McKittrick, Brian
    Czarniecki, Michael
    Greenlee, William
    Mullins, Deborra
    Guzzi, Mario
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (23) : 6801 - 6805
  • [47] Neuropeptide Y inhibits the trigeminovascular pathway through NPY Y1 receptor: implications for migraine
    Oliveira, Margarida-Martins
    Akerman, Simon
    Tavares, Isaura
    Goadsby, Peter J.
    PAIN, 2016, 157 (08) : 1666 - 1673
  • [48] Change in feeding behavior by knockdown of NPY Y1 receptor in mouse paraventricular nucleus-by in situ hybridization and immunohistochemistry
    Shiiya, Tomohiro
    Murase, Shin-ichi
    Higuchi, Hiroshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 257P - 257P
  • [49] Effect in feeding behavior by knockdown of NPY Y1 and Y5 receptor in mouse paraventricular nucleus using siRNA vector
    Shiiya, Tomohiro
    Murase, Shin-ichi
    Higuchi, Hiroshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112 : 184P - 184P
  • [50] Activation of the neuropeptide Y (NPY) Y1 receptor suppresses EAE via the inhibition of autoreactive Th1 responses in vivo
    Bedoui, S
    Miyake, S
    Lin, Y
    Miyamoto, K
    Oki, S
    Kawamura, N
    Beck-Sickinger, A
    von Hörsten, S
    Yamamura, T
    JOURNAL OF NEUROIMMUNOLOGY, 2004, 154 (1-2) : 77 - 77